Relationship between maternal thyroid hormones and the biochemical markers of the first trimester aneuploidy screening
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The role of thyroid function in biochemical markers of first trimester screening has not been assessed. The aim of the present study was to investigate if there were any relation between maternal thyroid hormones and free-beta subunit of human chorionic gonadotropin (fβ-hCG) and pregnancy-associated plasma protein A (PAPP-A) levels as the biochemical markers of the combined first trimester aneuploidy screening.
375 pregnant women between 11 and 14 weeks of gestation who were offered routine first trimester prenatal aneuploidy screening and whose thyroid hormone levels (Thyroid stimulating hormone (TSH), free and total thyroxine, free and total triiodothyronine, anti thyroid peroxidase antibody) were measured were assessed. Correlation of free-β-hCG and PAPP-A with maternal thyroid hormones was analyzed.
There was no statistically significant correlation between maternal TSH, free and total thyroxine, free and total triiodothyronine, anti-thyroid peroxidase antibodies and free-β-hCG and PAPP-A as biochemical markers of first trimester aneuploidy screening.
Maternal thyroid function does not seem to affect secretion of fβ-hCG and PAPP-A.
- Relationship between maternal thyroid hormones and the biochemical markers of the first trimester aneuploidy screening
Archives of Gynecology and Obstetrics
Volume 287, Issue 6 , pp 1125-1129
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- Print ISSN
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- First trimester
- Prenatal screening
- Thyroid hormones
- Anti thyroid peroxidase
- Industry Sectors
- Author Affiliations
- 1. Department of Obstetrics and Gynecology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey
- 3. Fatih Mah., Adnan Menderes Bulvarı, 30014 Sok., Yalı Apt, 7/14, Mezitli, Mersin, Turkey
- 2. Department of Biochemistry, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey