Archives of Gynecology and Obstetrics

, Volume 287, Issue 1, pp 1–7

Thyroid (dys-)function in normal and disturbed pregnancy

  • Brigitte K. Budenhofer
  • Nina Ditsch
  • Udo Jeschke
  • Roland Gärtner
  • Bettina Toth
Maternal-Fetal Medicine

DOI: 10.1007/s00404-012-2592-z

Cite this article as:
Budenhofer, B.K., Ditsch, N., Jeschke, U. et al. Arch Gynecol Obstet (2013) 287: 1. doi:10.1007/s00404-012-2592-z



During pregnancy, physiologic changes in maternal thyroid function take place especially due to hormonal as well as metabolic processes. Human chorionic gonadotropin activates the maternal thyroid gland leading to increased thyroid hormone production. A sufficient availability of maternal thyroid hormones is essential for fetal development, especially during the first trimester of pregnancy, when the fetal thyroid gland is not yet functional.

Materials and Methods

Current knowledge of thyroid dysfunction including thyroid autoimmunity, hypothyroidism or hyperthyroidism is summarized with special focus on miscarriage and pregnancy disorders. Therefore, a Medline research as well as an analysis of current guidelines on thyroid function and pregnancy was performed.


A study focusing on TSH levels in normal and disturbed pregnancies, the risk of miscarriage in association with thyroid autoantibodies, and (subclinical) hypothyroidism in infertile and fertile women were included.


Maternal thyroid dysfunction negatively affects pregnancy outcome. Besides a routine iodine supplementation in pregnant women and treatment of hypo as well as hyperthyroidism, TSH levels should routinely be measured in women during childbearing years and adjusted to concentrations <2.5 mIU/l in order to optimize maternal health and fetal development.


Pregnancy Miscarriage Thyroid dysfunction Hypothyroidism Hyperthyroidism Thyroid autoimmunity Hashimoto’s thyroiditis 

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Brigitte K. Budenhofer
    • 1
  • Nina Ditsch
    • 2
  • Udo Jeschke
    • 1
  • Roland Gärtner
    • 3
  • Bettina Toth
    • 4
  1. 1.Department of Obstetrics and GynecologyLudwig-Maximilians UniversityMunichGermany
  2. 2.Department of Obstetrics and GynecologyLudwig-Maximilians UniversityMunichGermany
  3. 3.Department of EndocrinologyLudwig-Maximilians UniversityMunichGermany
  4. 4.Department of Gynecological Endocrinology and Fertility DisordersRuprechts-Karls University HeidelbergHeidelbergGermany

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