Archives of Gynecology and Obstetrics

, Volume 287, Issue 1, pp 9–14

First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies

  • Takashi Yamada
  • Mamoru Morikawa
  • Takahiro Yamada
  • Reiko Kishi
  • Kazuo Sengoku
  • Toshiaki Endo
  • Tsuyoshi Saito
  • Kazutoshi Cho
  • Hisanori Minakami
Maternal-Fetal Medicine

DOI: 10.1007/s00404-012-2501-5

Cite this article as:
Yamada, T., Morikawa, M., Yamada, T. et al. Arch Gynecol Obstet (2013) 287: 9. doi:10.1007/s00404-012-2501-5

Abstract

Objectives

To determine whether a low serum folate level during the first trimester predicts subsequent late abortion, preterm birth, or fetal growth restriction (FGR).

Study design

A prospective cohort study involving 5,075 women whose serum folate levels were measured during the first trimester. The participants were informed of their serum folate levels.

Results

The pregnancy duration, birthweight, rate of late abortion/preterm birth, and the rate of FGR did not differ significantly among the four groups classified according to folate status. The mean serum folate levels did not differ among quartiles classified according to the gestational week at the time of delivery. Nineteen of the 20 women with folate deficiency gave birth at term to infants with a birthweight of 3.132 ± 321 g; only one infant had FGR.

Conclusion

Low serum folate levels during the first trimester were not associated with the risk of late abortion, preterm birth, or FGR.

Keywords

Abortion Nutrition Preterm birth Serum folate 

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Takashi Yamada
    • 1
  • Mamoru Morikawa
    • 1
  • Takahiro Yamada
    • 1
  • Reiko Kishi
    • 2
  • Kazuo Sengoku
    • 3
  • Toshiaki Endo
    • 4
  • Tsuyoshi Saito
    • 4
  • Kazutoshi Cho
    • 1
  • Hisanori Minakami
    • 1
  1. 1.Department of ObstetricsHokkaido University Graduate School of MedicineSapporoJapan
  2. 2.Center for Environmental and Health SciencesHokkaido UniversitySapporoJapan
  3. 3.Department of Obstetrics and GynecologyAsahikawa Medical University Graduate School of MedicineAsahikawaJapan
  4. 4.Department of Obstetrics and GynecologySapporo Medical UniversitySapporoJapan

Personalised recommendations