Sister Mary Joseph’s nodule associated with rare endometrial squamous cell carcinoma
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- Rahman, M.T., Nakayama, K., Rahman, M. et al. Arch Gynecol Obstet (2012) 286: 711. doi:10.1007/s00404-012-2356-9
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Umbilical metastasis (Sister Mary Joseph’s nodule) is a rare physical sign seen only in 1–3 % of patients with an intra-abdominal and/or pelvic malignancy. Here, we present a case of Sister Mary Joseph’s (SMJN) nodule originating from a primary squamous cell carcinoma of the endometrium, a rare histological subtype.
SMJN was detected in a 30-year-old woman after a preoperative CT scan for a suspected umbilical hernia. Subsequent laparotomy and histopathological examination confirmed endometrial squamous cell carcinoma metastasizing to the umbilical region.
The SMJN may be the first presenting sign of an intra-abdominal and/or pelvic malignancy and may co-exist with an umbilical hernia. Therefore, malignancy should be considered one of the differentials of an umbilical mass.
KeywordsSister Mary Joseph’s noduleUmbilical herniaPrimary endometrial squamous cell carcinoma
Sister Mary Joseph’s nodule
Primary endometrial squamous cell carcinoma