Gynecologic Oncology

Archives of Gynecology and Obstetrics

, Volume 286, Issue 3, pp 711-715

First online:

Sister Mary Joseph’s nodule associated with rare endometrial squamous cell carcinoma

  • Mohammed Tanjimur RahmanAffiliated withDepartment of Obstetrics and Gynecology, Shimane University School of Medicine
  • , Kentaro NakayamaAffiliated withDepartment of Obstetrics and Gynecology, Shimane University School of Medicine Email author 
  • , Munmun RahmanAffiliated withDepartment of Obstetrics and Gynecology, Shimane University School of Medicine
  • , Naomi NakayamaAffiliated withDepartment of Biochemistry, Shimane University School of Medicine
  • , Masako IshikawaAffiliated withDepartment of Obstetrics and Gynecology, Shimane University School of Medicine
  • , Atsuko KatagiriAffiliated withDepartment of Obstetrics and Gynecology, Shimane University School of Medicine
  • , Hiroshi KatagiriAffiliated withDepartment of Obstetrics and Gynecology, Shimane University School of Medicine
  • , Tomoka IshibashiAffiliated withDepartment of Obstetrics and Gynecology, Shimane University School of Medicine
  • , Kouji IidaAffiliated withDepartment of Obstetrics and Gynecology, Shimane University School of Medicine
    • , Kohji MiyazakiAffiliated withDepartment of Obstetrics and Gynecology, Shimane University School of Medicine

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Abstract

Background

Umbilical metastasis (Sister Mary Joseph’s nodule) is a rare physical sign seen only in 1–3 % of patients with an intra-abdominal and/or pelvic malignancy. Here, we present a case of Sister Mary Joseph’s (SMJN) nodule originating from a primary squamous cell carcinoma of the endometrium, a rare histological subtype.

Case history

SMJN was detected in a 30-year-old woman after a preoperative CT scan for a suspected umbilical hernia. Subsequent laparotomy and histopathological examination confirmed endometrial squamous cell carcinoma metastasizing to the umbilical region.

Conclusion

The SMJN may be the first presenting sign of an intra-abdominal and/or pelvic malignancy and may co-exist with an umbilical hernia. Therefore, malignancy should be considered one of the differentials of an umbilical mass.

Keywords

Sister Mary Joseph’s nodule Umbilical hernia Primary endometrial squamous cell carcinoma