Archives of Gynecology and Obstetrics

, Volume 286, Issue 2, pp 511–516

Transfer of blastocysts derived from frozen-thawed cleavage stage embryos improved ongoing pregnancy

  • Maryam Eftekhar
  • Abbas Aflatoonian
  • Farnaz Mohammadian
  • Nasim Tabibnejad
Reproductive Medicine

DOI: 10.1007/s00404-012-2303-9

Cite this article as:
Eftekhar, M., Aflatoonian, A., Mohammadian, F. et al. Arch Gynecol Obstet (2012) 286: 511. doi:10.1007/s00404-012-2303-9
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Abstract

Purpose

The aim of our study was to compare the transfer of embryos that are cryopreserved in cleavage stage after thawing with the transfer of embryos after thawing and culture in sequential media until blastocyst formation.

Methods

In this prospective clinical study, we have evaluated 134 cycles of ART treatment for infertility. Frozen embryos were thawed and then cultured in sequential media until blastocyst stage in blastocyst group and were compared with thawed embryos in cleavage stage group.

Results

Implantation rate was significantly higher in blastocyst group (30 %) compared to cleavage group (17 %). No statistical differences were reported in chemical and clinical pregnancy rates between groups. Ongoing pregnancy rate was significantly higher in blastocyst group compared to cleavage group (42.9 vs. 24.6 %).

Conclusions

Our results indicated that blastocyst formation after thawing of cleavage stage embryos is a good predictor for embryo viability and pregnancy outcome.

Keywords

BlastocystCryopreserved embryoCleavage embryoPregnancy outcome

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Maryam Eftekhar
    • 1
  • Abbas Aflatoonian
    • 1
  • Farnaz Mohammadian
    • 2
  • Nasim Tabibnejad
    • 1
  1. 1.Department of Obstetrics and Gynecology, Research and Clinical Center for InfertilityShahid Sadoughi University of Medical SciencesYazdIran
  2. 2.Department of Obstetrics and GynecologyZanjan University of Medical SciencesZanjanIran