Maternal-Fetal Medicine

Archives of Gynecology and Obstetrics

, Volume 285, Issue 4, pp 891-899

Relationships among maternal nutrient intake and placental biomarkers during the 1st trimester in low-income women

  • Eileen R. FowlesAffiliated withThe University of Texas at Austin, School of Nursing Email author 
  • , Lorraine O. WalkerAffiliated withThe University of Texas at Austin, School of Nursing
  • , C. Nathan MartiAffiliated withDivision of Statistics and Scientific Computation, The University of Texas at Austin, College of Natural Sciences
  • , Roberta Jeanne RuizAffiliated withThe University of Texas at Austin, School of Nursing
  • , Joel WommackAffiliated withThe University of Texas at Austin, School of Nursing
  • , Miranda BryantAffiliated withThe University of Texas at Austin, School of Nursing
  • , SungHun KimAffiliated withThe University of Texas at Austin, School of Nursing
  • , Gayle M. TimmermanAffiliated withThe University of Texas at Austin, School of Nursing

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Abstract

Purpose

Pre-eclampsia is a multi-system disorder caused by inadequate placentation in early pregnancy; however, little is known about the influence of nutrient intake on placental development during the crucial 1st trimester. The objective of this study was to examine the relationships between nutrient intake and the raw values and ratios of angiogenic [placental growth factor (PlGF)] and antiangiogenic [soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng)] placental biomarkers in the 1st trimester.

Methods

A cross-sectional study of low-income, pregnant women (n = 118). Average nutrient intake was calculated from three 24-h dietary recalls. Biomarker values were adjusted for gestational age and nutrients were adjusted for energy.

Results

The angiogenic to antiangiogenic ratio [PlGF/(sFlt-1 × sEng)] was positively related to intake of vitamin D (r = 0.24), vitamin B2 (r = 0.25), B12 (r = 0.20), dietary folate equivalents (r = 0.19), iron (r = 0.19), and zinc (r = 0.19) and negatively related to transfats (r = −0.24). Principal component analysis revealed that a vitamin/mineral factor [t (112) = 2.58, p = 0.011] and transfats factor [t (112) = −2.03, p = 0.045] were significant predictors of the PlGF/(sFlt-1 × sEng) ratio. The vitamin and mineral factor was a significant predictor of sFlt-1 [t (122) = 2.29, p = 0.024].

Conclusions

Expression of placental biomarkers in the early weeks of pregnancy may be influenced by intake of nutrients. Understanding the influence of maternal nutrient intake and placental development in the 1st trimester may provide the opportunity to avert the development or blunt the severity of preeclampsia.

Keywords

Preeclampsia Vitamin D Transfats Pregnancy Low income Placental growth factor Soluble fms-like tyrosine kinase-1 Soluble endoglin