Archives of Gynecology and Obstetrics

, Volume 285, Issue 3, pp 791–795

Pregnancy outcome in patients with stage 1a endometrial adenocarcinoma, who conservatively treated with megestrol acetate

  • Elham Shirali
  • Fariba Yarandi
  • Zahra Eftekhar
  • Hadi Shojaei
  • Zahra Khazaeipour
Gynecologic Oncology

DOI: 10.1007/s00404-011-2021-8

Cite this article as:
Shirali, E., Yarandi, F., Eftekhar, Z. et al. Arch Gynecol Obstet (2012) 285: 791. doi:10.1007/s00404-011-2021-8

Abstract

Objective

The most effective treatment of well-differentiated endometrial carcinoma is surgery. The aim of this study is the evaluation of megestrol acetate on young patients with well-differentiated endometrial cancer who wish to preserve their fertility, with regard to the receptors.

Methods

16 patients were treated initially with 160 mg/d of megestrol acetate and continued with 320 mg/d for non-responsive cases. All patients followed with FD&C and hysteroscopy. The responsive patients were referred to IVF group.

Results

Response rate to hormonal therapy was 10/16 (62.5%). The mean time of responding was 7.5 months. Other six (37.5%) patients underwent total abdominal hysterectomy (TAH).

Of 10 patients who responded to hormonal therapy, one exited of the study because of her husband’s infertility. Two patients are under IVF. Three patients did not get pregnant and four patients became pregnant and finally underwent TAH.

All patients had progesterone receptors. Only one patient lacked estrogen receptors; who also responded to treatment.

Conclusion

Progestins treatment of these patients who want to have child may be useful, but close long-term follow-up is necessary. The evaluation of estrogen and progesterone receptors assay may be useful in predicting response to the treatment.

Keywords

Hormonal therapyPregnancyProgesterone receptorWell-differentiated endometrial carcinoma

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Elham Shirali
    • 1
  • Fariba Yarandi
    • 2
  • Zahra Eftekhar
    • 2
  • Hadi Shojaei
    • 2
  • Zahra Khazaeipour
    • 3
  1. 1.Department of Obstetrics and Gynecology, Women Hospital (Mirza Koochackhan)Tehran University of Medical SciencesTehranIran
  2. 2.Department of Gynecology Oncology, Women Hospital (Mirza Koochackhan)Tehran University of Medical SciencesTehranIran
  3. 3.Preventive and Community Medicine Specialist, Brain and Spinal Injury Repair Research CenterImam Khomeini Hospital Complex, Tehran University of Medical SciencesTehranIran