PAPP-A levels of late pregnancy in preeclampsia and HELLP syndrome
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To determine the relationship between pregnancy-associated plasma protein-A (PAPP-A) levels and preeclampsia and HELLP syndrome at last trimester and to investigate if the severity of preeclampsia would be associated with PAPP-A levels.
Four groups were constructed; mild-preeclampsia group consisted of 19 women, severe-preeclampsia group 17, HELLP group 5 and control group 32 women. All groups were matched strictly for gestational age at last trimester. Maternal blood samples for PAPP-A were collected as soon as the patients were diagnosed as preeclampsia or HELLP syndrome at last trimester and compared.
Mean ages of participants, parity, gestational week, and fetal weights were similar. Mean PAPP-A levels were significantly higher in preeclampsia and HELLP groups compared to control group. PAPP-A levels were not different among mild-severe preeclampsia and HELLP groups. There was significant, positive and strong correlation between gestational age and PAPP-A level and also between fetal weight and PAPP-A levels (correlation coefficents = 0.83 and 0.78 respectively).
PAPP-A level at last trimester increases in all mild-severe preeclampsia and HELLP syndrome, but is not predictive for severity of preeclampsia or HELLP syndrome.
- Davison JM, Homuth V, Jeyabalan A et al (2004) New aspects in the pathophysiology of Preeclampsia. J Am Soc Nephrol 15:2440–2448 CrossRef
- Dugoff L, Lynch AM, Cioffi-Ragan D, Hobbins JC, Schultz LK, Malone FD, D’Alton ME (2005) FASTER Trial Research Consortium First trimester uterine artery Doppler abnormalities predict subsequent intrauterine growth restriction. Am J Obstet Gynecol 193:1208–1212 CrossRef
- Laursen LS, Overgaard MT, Søe R, Boldt HB, Sottrup-Jensen L, Giudice LC, Conover CA, Oxvig C (2001) Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A. FEBS Lett 504:36–40 CrossRef
- Spencer K, Yu CK, Savvidou M, Papageorghiou AT, Nicolaides KH (2006) Prediction of pre-eclampsia by uterine artery Doppler ultrasonography and maternal serum pregnancy-associated plasma protein-A, free beta-human chorionic gonadotropin, activin A and inhibin A at 22 + 0 to 24 + 6 weeks’ gestation. Ultrasound Obstet Gynecol 27(6):658–663 CrossRef
- Folkersen J, Grudzinskas JG, Hindersson P, Teisner B, Westergaard JG (1981) Pregnancy-associated protein-A circulating levels during normal pregnancy. Am J Obstet Gynecol 139:910–914
- Ong CY, Liao AW, Spencer K et al (2000) First trimester maternal serum free beta human chorionic gonadotrophin and pregnancy associated plasma protein A as predictors of pregnancy complications. Brit J Obstet Gynaecol 107:1265–1270 CrossRef
- Silver HM, Lambert-Messerlian GM, Star JA, Hogan J, Canick JA (1999) Comparison of maternal serum total activin A and inhibin A in normal, preeclamptic, and nonproteinuric gestationally hypertensive pregnancies. Am J Obstet Gynecol 180:1131–1137 CrossRef
- Muttukrishna S, Knight PG, Groome NP, Redman CW, Ledger WL (1997) Activin A and inhibin A as possible endocrine markers for pre-eclampsia. Lancet 349:1285–1288 CrossRef
- Cuckle H, Sehmi I, Jones R (1998) Maternal serum inhibin A can predict pre-eclampsia. Br J Obstet Gynaecol 105:1101–1103 CrossRef
- McCarthy JF, Misra DN, Roberts JM (1999) Maternal plasma leptin is increased in preeclampsia and positively correlates with fetal cord concentration. Am J Obstet Gynecol 180:731–736 CrossRef
- Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH et al (2004) Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 350:672–683 CrossRef
- Venkatesha S, Toporsian M, Lam C, Hanai JI, Mammoto T, Kim YM, Bdolah Y, Lim KH, Yuan HT, Libermann TA et al (2006) Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med 12:642–649 CrossRef
- Yaron Y, Heifetz S, Ochshorn Y et al (2002) Decreased first trimester PAPP-A is a predictor of adverse pregnancy outcome. Prenat Diagn 22:778–782 CrossRef
- Smith GC, Stenhouse EJ, Crossley JA et al (2002) Early pregnancy levels of pregnancy associated plasma protein A and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth. J Clin Endocrinol Metabol 87:1762–1767 CrossRef
- Canini S, Prefumo F, Pastorino D et al (2008) Association between birth weight and first trimester free beta-human chorionic gonadotropin and pregnancy-associated plasma protein A. Fert Steril 89:174–178 CrossRef
- Hughes G, Bischof P, Wilson G, Klopper A (1980) Assay of a placental protein to determine fetal risk. BMJ 280:671–673 CrossRef
- Toop K, Klopper A (1981) Concentration of pregnancy-assocated plasma protein A (PAPP-A) in patients with pre-eclamptic toxaemia. Placenta Suppl 3:167–173
- Bersinger NA, Groome N, Muttukrishna S (2002) Pregnancy associated and placental proteins in the placental tissue of normal pregnant women and patients with preeclampsia at term. Eur J Endocrinol 147:785–793 CrossRef
- Bersinger NA, Smárason AK, Muttukrishna S, Groome NP, Redman CW (2003) Women with preeclampsia have increased serum levels of pregnancy-associated plasma protein A (PAPP-A), inhibin A, activin A and soluble E-selectin. Hypertens Pregnancy 22:45–55 CrossRef
- Deveci K, Sogut E, Evliyaoglu O, Duras N (2009) Pregnancy-associated plasma protein-A and C-reactive protein levels in pre-eclamptic and normotensive pregnant women at third trimester. J Obstet Gynaecol Res 35:94–98 CrossRef
- Westergaard JG, Teisner B (1982). Pregnancy-associated plasma protein A in normal and abnormal late pregnancy. In: Grudzinskas JG, Teisner B, Seppala M, eds. Pregnancy proteins. Sydney Academic Press, pp 345–354.
- Nishizawa H, Pryor-Koishi K, Suzuki M, Kato T, Kogo H, Sekiya T, Kurahashi H, Udagawa Y (2008) Increased levels of pregnancy-associated plasma protein-A2 in the serum of pre-eclamptic patients. Mol Hum Reprod 14:595–602 CrossRef
- Farr M, Strube J, Geppert HG, Kocourek A, Mahne M, Tschesche H (2000) Pregnancy-associated plasma protein-E (PAPP-E). Biochim Biophys Acta 1493:356–362
- Overgaard MT, Boldt HB, Laursen LS, Sottrup-Jensen L, Conover CA, Oxvig C (2001) Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase. J Biol Chem 276:21849–21853 CrossRef
- PAPP-A levels of late pregnancy in preeclampsia and HELLP syndrome
Archives of Gynecology and Obstetrics
Volume 285, Issue 1 , pp 45-49
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- Author Affiliations
- 1. Obstetrics and Gynecology Department, Sisli Etfal Training and Research Hospital, Istanbul, Turkey
- 2. Medicosocial Unit, Istanbul University Cerrahpasa Medical Faculty, Atakent Mah, Soyak Olimpiakent Sitesi D: 12 Blok, D53, 34303, Kucukcekmece, Halkali, Istanbul, Turkey
- 3. Istanbul University Cerrahpasa Medical Faculty, Kucukcekmece, Halkali, Istanbul, 34303, Turkey
- 4. Department of Biochemistry, Sisli Etfal Training and Research Hospital, Istanbul, Turkey