Archives of Gynecology and Obstetrics

, Volume 285, Issue 1, pp 45–49

PAPP-A levels of late pregnancy in preeclampsia and HELLP syndrome

  • Alev Atis
  • Yavuz Aydin
  • Elif Basol
  • Semih Kaleli
  • Fatma Turgay
  • Nimet Goker
Materno-Fetal Medicine

DOI: 10.1007/s00404-011-1912-z

Cite this article as:
Atis, A., Aydin, Y., Basol, E. et al. Arch Gynecol Obstet (2012) 285: 45. doi:10.1007/s00404-011-1912-z

Abstract

Purpose

To determine the relationship between pregnancy-associated plasma protein-A (PAPP-A) levels and preeclampsia and HELLP syndrome at last trimester and to investigate if the severity of preeclampsia would be associated with PAPP-A levels.

Methods

Four groups were constructed; mild-preeclampsia group consisted of 19 women, severe-preeclampsia group 17, HELLP group 5 and control group 32 women. All groups were matched strictly for gestational age at last trimester. Maternal blood samples for PAPP-A were collected as soon as the patients were diagnosed as preeclampsia or HELLP syndrome at last trimester and compared.

Results

Mean ages of participants, parity, gestational week, and fetal weights were similar. Mean PAPP-A levels were significantly higher in preeclampsia and HELLP groups compared to control group. PAPP-A levels were not different among mild-severe preeclampsia and HELLP groups. There was significant, positive and strong correlation between gestational age and PAPP-A level and also between fetal weight and PAPP-A levels (correlation coefficents = 0.83 and 0.78 respectively).

Conclusion

PAPP-A level at last trimester increases in all mild-severe preeclampsia and HELLP syndrome, but is not predictive for severity of preeclampsia or HELLP syndrome.

Keywords

PAPP-A Severe-preeclampsia Mild-preeclampsia HELLP syndrome 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Alev Atis
    • 1
  • Yavuz Aydin
    • 2
  • Elif Basol
    • 1
  • Semih Kaleli
    • 3
  • Fatma Turgay
    • 4
  • Nimet Goker
    • 1
  1. 1.Obstetrics and Gynecology DepartmentSisli Etfal Training and Research HospitalIstanbulTurkey
  2. 2.Medicosocial UnitIstanbul University Cerrahpasa Medical FacultyKucukcekmece, HalkaliTurkey
  3. 3.Istanbul University Cerrahpasa Medical FacultyKucukcekmece, HalkaliTurkey
  4. 4.Department of BiochemistrySisli Etfal Training and Research HospitalIstanbulTurkey