Archives of Gynecology and Obstetrics

, Volume 284, Issue 6, pp 1411–1416

Neonatal outcome of IVF singletons versus naturally conceived in women aged 35 years and over

Materno-fetal Medicine

DOI: 10.1007/s00404-011-1873-2

Cite this article as:
Tomic, V. & Tomic, J. Arch Gynecol Obstet (2011) 284: 1411. doi:10.1007/s00404-011-1873-2



To compare the delivery and neonatal outcome of IVF singleton pregnancies with those conceived spontaneously in primiparous women ≥35 years of age.


Data were collected by the hospital’s obstetrics and pediatric staff at the time of examination, hospitalization, delivery and discharge. A total of 283 women with in vitro fertilization (IVF) singleton deliveries were matched according to ethnicity, age, gravidity, smoking habits, body mass index, weight gain in pregnancy, site and time of delivery with consecutive 283 women conceived spontaneously. The outcome measures were mode of delivery, birth weight, preterm birth and perinatal mortality.


Cesarean delivery rate was more common in IVF pregnancies (39.9% vs. 25.1%; p < 0.001). Preterm delivery rate, specifically of spontaneous onset was significantly higher in IVF group (18.7%) than in spontaneous conception group (10.3%; p < 0.008). No difference was found in birth weight records (SGA, VLBW, LBW and LGA) or perinatal mortality rate. However, average gestational birth weight was lower among infants conceived after IVF (3,050 ± 587 g vs. 3,130 ± 524 g; p < 0.05).


Singleton IVF pregnancies in primiparous women ≥35 years of age have increased perinatal risk associated with higher rates of cesarean section, preterm births and infants of lower average birth weight. Nevertheless, pregnancy and delivery complications, number of infants with low or very low birth weight, small or large birth weight for appropriate gestation did not differ from those of the spontaneous conceptions.


Advanced maternal age In vitro fertilization Mode of delivery Neonatal outcome 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Department of Human ReproductionUniversity Hospital Center “Sisters of Mercy”ZagrebCroatia

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