Archives of Gynecology and Obstetrics

, Volume 284, Issue 4, pp 813–819

Maternal early pregnancy body mass index and risk of preterm birth

Authors

  • Ting Wang
    • School of Public Health Peking University Health Science Center
    • Tanggu Center for Disease Control and Prevention
  • Jun Zhang
    • Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine
  • Xinrong Lu
    • School of Public Health Peking University Health Science Center
  • Wei Xi
    • School of Public Health Peking University Health Science Center
    • School of Public HealthTianjin Medical University
    • School of Public Health Peking University Health Science Center
Materno-fetal Medicine

DOI: 10.1007/s00404-010-1740-6

Cite this article as:
Wang, T., Zhang, J., Lu, X. et al. Arch Gynecol Obstet (2011) 284: 813. doi:10.1007/s00404-010-1740-6

Abstract

Objective

To determine the association between maternal body mass index (BMI) in early pregnancy and the risk of preterm birth (PTB) in Chinese women.

Methods

Data were obtained from a population-based perinatal care program in China during 1993–2005. Women whose height and weight information was recorded at the first prenatal visit in the first trimester of pregnancy and delivered a singleton live infant were selected. Women with multiple gestations, stillbirths, delivery before 28 weeks or after 44 weeks of gestation, and infants affected by major external birth defects were excluded. BMI was categorized as underweight (less than 18.5 kg/m2), normal weight (18.5–23.9 kg/m2), overweight (24–27.9 kg/m2), and obese (≥28 kg/m2) based on BMI classification criteria for Chinese. Logistic regression analysis was conducted to adjust for potential confounders, such as maternal age, education, occupation, city or county, gender of infant, and year of delivery.

Results

A total of 353,477 women were selected. The incidence of preterm birth in women who were underweight, normal weight, overweight, obese was 3.69% (3.61–3.76%), 3.59% (3.55–3.62%), 3.83% (3.71–3.96%), 4.90% (4.37–5.43%), respectively. The incidence of elective preterm birth, overweight, and obesity increased remarkably during 2000–2005 compared with that during 1993–1996. After having adjusted for potential confounders including maternal age, maternal occupation, education, city or county, gender of the infant and year of birth, the risk of PTB increased significantly with BMI (P < 0.05). Among nulliparae, the risk of elective preterm birth increased with increasing BMI. Nulliparae who were underweight were less likely to deliver elective preterm births (OR = 0.89, 95% CI 0.80–0.98). Nulliparae who were overweight and obese in early pregnancy were at a greater risk of elective PTB than normal weight nulliparae (for the overweight OR = 1.36, 95% CI 1.18–1.56, for the obese OR = 2.94, 95% CI 2.04–4.25).

Conclusion

In this study, indigenous Chinese cohort women who are overweight, obese, and nulliparous are at an increased risk of elective preterm birth.

Keywords

Preterm birthBody mass indexEarly pregnancyParityObesity

Abbreviations

BMI

Body mass index

CI

Confidence interval

IRB

Institutional review board

MCH

Maternity and child health

NCMIH

National Center for Maternal and Infant Health

OR

Odds ratio

PTB

Preterm birth

PHCSS

Perinatal Health Care Surveillance System

SD

Standard deviation

Copyright information

© Springer-Verlag 2010