Archives of Gynecology and Obstetrics

, Volume 282, Issue 5, pp 547–551

Management of fertility preservation in young breast cancer patients in a large breast cancer centre

  • B. Lawrenz
  • E. Neunhoeffer
  • M. Henes
  • S. Lessmann-Bechle
  • B. Krämer
  • Tanja Fehm
Reproductive Medicine

DOI: 10.1007/s00404-010-1523-0

Cite this article as:
Lawrenz, B., Neunhoeffer, E., Henes, M. et al. Arch Gynecol Obstet (2010) 282: 547. doi:10.1007/s00404-010-1523-0

Abstract

Purpose

The increase of breast cancer in young women under 40 years and the increasing age of women at the time of the birth of their first child underlines the importance to implement counselling for fertility-preserving strategies in the management of breast cancer care. We present the fertility-preserving procedures performed after routine counselling for primary breast cancer patients in a large certified breast cancer centre.

Materials and methods

Since November 2006, patients aged below 40 years with histologically confirmed breast cancer are routinely counselled on fertility-preserving possibilities before breast surgery and chemotherapy in the fertility centre of the University Women’s Hospital in Tuebingen. The recommendations are based on the treatment recommendations of the network FertiPROTEKT.

Results

During the last 40 months, 56 primary breast cancer patients were counselled. Forty-one of these patients were hormone receptor positive. Thirty-four patients (63%) underwent fertility-preserving strategies. The majority of the patients (n = 22) decided on ovarian tissue cryopreservation. GnRH protection was performed in 14 patients. In 12 patients an ovarian stimulation protocol was initiated to cryopreserve fertilized or unfertilized oocytes. A combination of different fertility-preserving methods was performed in 12 patients.

Conclusions

The preservation of ovarian function and fertility are of great importance to young breast cancer patients. Counselling on fertility-preserving strategies is therefore critical in these patients and should be routinely performed.

Keywords

Breast cancer chemotherapy Fertility Fertility-preserving methods Cryopreservation 

Abbreviations

CMF

Cyclophosphamide, methotrexate, fluorouracil

FEC

Fluorouracil, epirubicin, cyclophosphamide

FAC

Fluorouracil, adriamycin, cyclophosphamide

EC

Epirubicin, cyclophosphamide

AC

Adriamycin, cyclophosphamide

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • B. Lawrenz
    • 1
  • E. Neunhoeffer
    • 1
  • M. Henes
    • 1
  • S. Lessmann-Bechle
    • 1
  • B. Krämer
    • 1
  • Tanja Fehm
    • 1
  1. 1.Department of Obstetrics and GynecologyUniversity of TuebingenTübingenGermany