Archives of Gynecology and Obstetrics

, Volume 283, Issue 1, pp 71–77

Randomized, controlled study of the effects of raloxifene on high sensitivity C-reactive protein and serum lipids

General Gynecology

DOI: 10.1007/s00404-009-1292-9

Cite this article as:
Oztas, E. & Kurtay, G. Arch Gynecol Obstet (2011) 283: 71. doi:10.1007/s00404-009-1292-9

Abstract

Objective

To investigate the effects of raloxifene, on serum lipids and high-sensitivity C-reactive protein (hs-CRP) in healthy postmenopausal women.

Methods

We studied the effect of raloxifene, on serum lipids and hs-CRP in 85 healthy postmenopausal women. Participants were randomly assigned to 60 mg daily raloxifene (43 subjects) for 6 months; the rest of the subjects were in the control group. Serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, triglyceride and hs-CRP levels were measured at baseline and at the sixth month in both groups.

Results

Raloxifene treatment resulted in a 26% reduction in serum hs-CRP concentrations at the sixth month, compared with the baseline levels (P < 0.05). At the sixth month, TC and LDL-C levels were significantly reduced by 60 mg daily raloxifene (6.8 and 5.6%, respectively) when compared with both the baseline levels and the control group.

Conclusion

The results of our study showed that raloxifene at a dose of 60 mg daily reduces serum TC, LDL-C and hs-CRP levels significantly in healthy postmenopausal women. According to the results of the current study, we suggest that raloxifene may have a favorable effect on the prevention of cardiovascular disease in healthy postmenopausal women.

Keywords

Menopause Raloxifene Lipids C-reactive protein 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of Obstetrics and Gynecology, Faculty of MedicineUfuk UniversityAnkaraTurkey
  2. 2.Department of Obstetrics and Gynecology, Faculty of MedicineAnkara UniversityAnkaraTurkey
  3. 3.AnkaraTurkey