, Volume 280, Issue 5, pp 725-727
Date: 24 Feb 2009

Lymphoepithelioma-like carcinoma of the uterine cervix

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Purpose

To elucidate the clinicopathologic features of lymphoepithelioma-like carcinoma (LELC) of the uterine cervix, we examined three Japanese cases.

Methods

We collected three cases of LELC of the uterine cervix between 2000 and 2007. We examined these patients’ clinicopathologic data, Epstein–Barr virus (EBV) and human papilloma virus (HPV) infectious status, and infiltrated lymphocyte population.

Results

Our patients had disease Fédération Internatinale de Gynécologie et d’Obstétrique stages I and II. All of them were free of disease at the time of the study. Macroscopically, one of the three tumors was polypoid. All tumor cells were negative for EBV and HPV using in situ hybridization and immunohistochemistry. The inflammatory background contained many CD3+ and CD8+ cells, but there were few CD4+, CD20+, or CD79a+ cells.

Conclusions

In our Japanese series, LELC of the uterine cervix showed good prognosis, and there is no relationship between this carcinoma and EBV or HPV infection.