Baseline characteristics and prevalence of HPV 6, 11, 16, 18 in young German women participating in phase III clinical trials of a quadrivalent HPV (6/11/16/18) vaccine
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As limited data among German women exist about HPV, Chlamydia trachomatis (CT) and Neisseria gonorrhoeae, we report the prevalence of these genital infections and general baseline demographics of the young German women enrolled in the phase III trials of the quadrivalent HPV vaccine.
Materials and methods
German females (n = 437; 9–23 years) were recruited among 3 international phase 3 studies of an HPV-6/11/16/18 vaccine. We present baseline characteristics, prevalence of HPV-6/11/16/18 and, for women aged 16–23, abnormal cervical cytology and sexually transmitted diseases.
Chlamydia trachomatis and Neisseria gonorrhoeae prevalence was 5 and 0.3%, respectively. Approximately 17% of participants had HPV-6, 11, 16, or 18 DNA or antibodies. All subjects <17 years were naïve to the four vaccine types.
The results of the vaccine trials have demonstrated that it is worth administering prophylactic HPV vaccines before sexual debut; however, none of these sexually active German women were positive to all four types and most were positive to only one type. Thus, all women had the potential to benefit from vaccination with a quadrivalent HPV vaccine.
- Baseline characteristics and prevalence of HPV 6, 11, 16, 18 in young German women participating in phase III clinical trials of a quadrivalent HPV (6/11/16/18) vaccine
Archives of Gynecology and Obstetrics
Volume 279, Issue 6 , pp 803-807
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- HPV prevalence
- Prophylactic quadrivalent HPV vaccine
- Cervical cytology
- Chlamydia trachomatis
- Neisseria gonorrhoeae
- Industry Sectors
- Author Affiliations
- 1. First Department of Obstetrics and Gynaecology – Klinikum Innenstadt, Ludwig-Maximilian-University Munich, Maistrasse 11, 80337, Munich, Germany
- 2. Universitaetsklinik Hamburg-Eppendorf, Hamburg, Germany
- 3. Charite University Hospital of Berlin, Berlin, Germany
- 4. The Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
- 5. Frauenklinik und Brustzentrum Rheinfelden, Rheinfelden, Germany
- 7. Maistrasse 11, 80337, Munich, Germany
- 6. Merck Research Laboratories, Westpoint, USA