Archives of Gynecology and Obstetrics

, Volume 279, Issue 4, pp 579–581

Term delivery following successful treatment of choriocarcinoma with brain metastases, a case report and review of literature


  • Nadereh Behtash
    • Gynecology Oncology Department, Vali-e-Asr HospitalTehran University of Medical Sciences
    • Kashan University of Medical Sciences
  • Bahareh Hamedi
    • Gynecology Obstetrics ResidentTehran University of Medical Sciences
  • Fatemeh Ramezanzadeh
    • Obstetrics Gynecology, Vali-e-Asr Reproductive Health Research CenterTehran University of Medical Sciences
Case Report

DOI: 10.1007/s00404-008-0753-x

Cite this article as:
Behtash, N., Behnamfar, F., Hamedi, B. et al. Arch Gynecol Obstet (2009) 279: 579. doi:10.1007/s00404-008-0753-x



Cerebral metastases from choriocarcinoma are a poor prognostic indicator of outcome in both the World Health Organization and FIGO classification systems. Although gestational trophoblastic neoplasia has become the most curable of gynecological malignancies, failure rate among “high-risk” patients is still high despite of the use of aggressive multidrug regimens.


A 27-year-old woman (G4P2Ab1) presented with hemiplegia due to brain metastases of choriocarcinoma 1 year after spontaneous abortion. She underwent craniotomy and was treated with nine courses of multiple agent etoposide, methotrexate, actinomycin- etoposide, and cisplatinum (EMA-EP) regimen combined with whole brain irradiation. She delivered a term healthy child 2 years after termination of treatment.


Multiagent EMA-EP chemotherapy and whole brain irradiation with craniotomy in selected patients preserves fertility and may improve a patient overall prognosis.


ChoriocarcinomaBrain metastasesEMA-EP

Copyright information

© Springer-Verlag 2008