Case Report

Archives of Gynecology and Obstetrics

, Volume 279, Issue 4, pp 579-581

First online:

Term delivery following successful treatment of choriocarcinoma with brain metastases, a case report and review of literature

  • Nadereh BehtashAffiliated withGynecology Oncology Department, Vali-e-Asr Hospital, Tehran University of Medical Sciences
  • , Fariba BehnamfarAffiliated withKashan University of Medical Sciences Email author 
  • , Bahareh HamediAffiliated withGynecology Obstetrics Resident, Tehran University of Medical Sciences
  • , Fatemeh RamezanzadehAffiliated withObstetrics Gynecology, Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access



Cerebral metastases from choriocarcinoma are a poor prognostic indicator of outcome in both the World Health Organization and FIGO classification systems. Although gestational trophoblastic neoplasia has become the most curable of gynecological malignancies, failure rate among “high-risk” patients is still high despite of the use of aggressive multidrug regimens.


A 27-year-old woman (G4P2Ab1) presented with hemiplegia due to brain metastases of choriocarcinoma 1 year after spontaneous abortion. She underwent craniotomy and was treated with nine courses of multiple agent etoposide, methotrexate, actinomycin- etoposide, and cisplatinum (EMA-EP) regimen combined with whole brain irradiation. She delivered a term healthy child 2 years after termination of treatment.


Multiagent EMA-EP chemotherapy and whole brain irradiation with craniotomy in selected patients preserves fertility and may improve a patient overall prognosis.


Choriocarcinoma Brain metastases EMA-EP