Cervical phosphorylated insulin-like growth factor binding protein-1 in prediction of preterm delivery
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- Altinkaya, O., Gungor, T., Ozat, M. et al. Arch Gynecol Obstet (2009) 279: 279. doi:10.1007/s00404-008-0703-7
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The aim of this study was to evaluate the phosphorylated isoform of insulin-like growth factor binding protein-1 (phIGFBP-1) in endocervical secretions as a predictor of preterm delivery in symptomatic and asymptomatic pregnant women.
The study included 105 patients between 24 and 34 weeks’ gestation with uterine contractions and 73 controls. Ph IGFBP-1 in cervical secretions was assessed in all patients by using a qualitative, immunochromatographic one-step dipstick test. Data analysis included Student’s test, Chi-Square, Fisher’s exact test and Kruskal Wallis variance analysis.
Preterm birth rate was 19.04% (20/105) in the study group. Of the 25 patients with a positive phIGFBP-1 test, mean gestational age at delivery was 32.8 ± 3.8, whereas of the 80 patients with a negative phIGFBP-1 test mean gestational age at delivery was 37.8 ± 2.5, in the study group (P < 0.05). The sensitivity, specificity, positive predictive value and negative predictive value for phIGFBP-1 in symptomatic patients were 70, 87.05, 56 and 92.5%, respectively, while in asymptomatic patients they were 40, 82.35, 14.28 and 94.91%, respectively.
The phIGFBP-1 in cervical secretions is a potential specific marker for preterm delivery occurring before 37 weeks. Also cervical detection of phIGFBP-1 by immunochromotography is a rapid and easily applicable test that highly predicts preterm delivery.