Unusually large extraintestinal GIST presenting as an abdomino-pelvic tumor
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- Matteo, D., Dandolu, V., Lembert, L. et al. Arch Gynecol Obstet (2008) 278: 89. doi:10.1007/s00404-007-0528-9
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Gastrointestinal stromal tumor (GIST) is a rare visceral tumor that may mimic ovarian tumor.
A 56-year-old woman presented with a large abdomino-pelvic mass and moderately elevated CA-125. A large tumor occupying the whole abdominal cavity and pelvis was noted on laparotomy. In addition, multiple tumor nodules were seen from the ligament of Treitz to the terminal ileum involving only the surface intestine. The ovaries appeared normal. The tumor demonstrated spindle and epithelioid components and was found to be morphologically and immunohistochemically consistent with GIST.
Gynecologists need to be cognizant of extra-ovarian pathology in the atypical presentation of a pelvic mass. Correct diagnosis is essential for proper management since GISTs specifically respond to the c-kit selective tyrosine kinase inhibitor, Imatinib mesylate.