Archives of Gynecology and Obstetrics

, Volume 276, Issue 5, pp 491–498

Cystic hygroma and lymphangioma: associated findings, perinatal outcome and prognostic factors in live-born infants

  • Ali Gedikbasi
  • Ahmet Gul
  • Akif Sargin
  • Yavuz Ceylan
Original Article

DOI: 10.1007/s00404-007-0364-y

Cite this article as:
Gedikbasi, A., Gul, A., Sargin, A. et al. Arch Gynecol Obstet (2007) 276: 491. doi:10.1007/s00404-007-0364-y

Abstract

Objectives

We aimed to determine associated ultrasonographic findings, chromosome abnormalities and the prognostic factors of cystic hygromas in live-born infants.

Methods

We reported a series of 57 cystic hygroma cases, who were diagnosed in the first and the second trimester of pregnancy by means of the ultrasonographic morphology of cystic hygroma, associated structural abnormalities, karyotype analysis and the autopsy findings. Survivors were followed for their fetal outcome and prognosis.

Results

There were 57 new cases of cystic hygroma among 8,155 screenings (0.7%). 35 of the cases (61.4%) were nonseptated and 22 of the cases (38.6%) were septated cystic hygroma. Chromosomal abnormalities were found in 23 of the cases (40.3%). The most common abnormality in nonseptated cystic hygroma was trisomy 21 (8 cases, 25%) and in septated cystic hygroma was Turner syndrome (4 cases, 21.1%). The most common associated structural malformations were cardiac abnormalities (in 7 cases, 20%) in nonseptated cystic hygroma cases and nonimmune hydrops (in 12 cases, 54.5%) in septated cystic hygroma cases. Overall survival was poor; only one case of septated cystic hygroma with axillary location and seven cases of nonseptated cystic hygroma, of whom two died in the neonatal period, were alive (10.5%). This study had 80% power to detect 0.03% difference in diagnosis cystic hygroma (α = 0.05, β = 0.80).

Conclusion

Fetuses with cystic hygroma are at high risk for adverse outcome. Prenatal diagnosis with invasive procedures should be done in order to inform the parents in detail. Axillary location of the hygroma and the depth of invasion had prognostic importance.

Keywords

Cystic hygromaKaryotypeAssociated abnormalitiesPrognostic factorsAxillary cystic hygroma

Abbreviations

CH

Cystic hygroma

TOP

Termination of pregnancy

VSD

Ventricular septal defect

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Ali Gedikbasi
    • 1
    • 2
  • Ahmet Gul
    • 1
  • Akif Sargin
    • 1
  • Yavuz Ceylan
    • 1
  1. 1.Department of Obstetrics and Gynecologyİstanbul Bakirkoy Maternity and Children Diseases HospitalIstanbulTurkey
  2. 2.IstanbulTurkey