Congenital cytomegalovirus infection in pregnancy: a case report of fetal death in a CMV-infected woman
The human cytomegalovirus (CMV) is universally distributed among human populations as one of the most common cause of congenital infection with an incidence of about 0.15–2.0% in developed countries. However, controversial data concerning intrauterine fetal death caused by CMV infection exist.
A case report.
In this case report we present a stillbirth in the 18th week of pregnancy, caused by a maternal serological and fetal histological congenital CMV infection.
Every attending physician and obstetrician should be aware of the possibility of a primary or even recurrent congenital CMV infection that could be a reason for sudden unknown congenital fetal death.
- Burny W, Liesnard C, Donner C, Marchant A (2004) Epidemiology, pathogenesis and prevention of congenital cytomegalovirus infection. Expert Rev Anti Infect Ther 2(6):881–894 CrossRef
- Gayant MA, Rours GIJG, Steegers EAP, Galama JMD, Semmekrot BA (2003) Congenital cytomegalie infection after recurrent infection: case reports and review of the literature. Eur J Pediatr 162:248–253
- Gaytant MA, Steegers EAP, Semmekrot BA, Merkus HM, Galama JMD (2002) Congenital cytomegalovirus infections: review of the epidemiology and outcome. Obstet Gynecol Surv 57(4):245–256 CrossRef
- Alford CA, Stagno S, Pass RF, Britt WJ (1990) Congenital and perinatal cytomegalovirus infections. Rev Infect Dis 12:745–751
- Ornoy A, Diac-Citrin O (2006) Fetal effects of primary and secondary cytomegalovirus infection in pregnancy. Reprod Oxicol 21:399–409 CrossRef
- Benshushan A, Brezinski A, Ben-David A, Nadjari M (1998) Early recurrent CMV infection with severe outcome to the fetus. Acta Obstet Gynecol Scand 77:694–695 CrossRef
- Diav-Citrin O, Gabbay R, Rahav G, Shechtman S, Arnon J, Ornoy A (2003) Cytomegalovirus in pregnancy: primary versus secondary infection: a prospective cohort study on 208 pregnancies. Birth Defects Res Clin Mol Teratol 67:317
- Revello MG, Gerna G (2002) Diagnosis and management of human cytomegalovirus infection in the mother, fetus and newborn infant. Clin Microbiol Rev 15:680–715 CrossRef
- Ahlfors K, Ivarsson SA, Harris S (2001) Secondary maternal cytomegalovirus infection—a significant cause of congenital disease. Pediatrics 107:1227–1228 CrossRef
- Rousseau T, Douvier S, Reynaud I, Laurent N, Bour JB, Durant C et al (2000) Severe fatal cytomegalic inclusion disease after documented maternal reactivation of cytomegalovirus infection during pregnancy. Prenat Diagn 20:333–336 CrossRef
- Yow M, Williamson D, Leeds L, Thompson P, Woodward R, Walmus B et al (1988) Epidemiologic characteristics of cytomegalovirus infection in mothers and their infants. Am J Obstet Gynecol 158:1189–1195
- Griffits P, Baboonian C (1984) A prospective study of primary cytomegalovirus infection during pregnancy: final report. Br J Obstet Gynaecol 91:307–315
- Moyo SR, Tswana SA, Nystrom L, Bergstrom S, Blomberg J, Ljugh A (1995) Intrauterine death and infections during pregnancy. Int J Gynaecol Obstet 51:211–218 CrossRef
- Eskild A, Jenum PA, Bruu A-L (2005) Maternal antibodies against cytomegalovirus in pregnancy and the risk of fetal death and low birth weight. Acta Obstet Gynecol Scand 84:1035–1041 CrossRef
- Pass RF, Boppona S (1999) Cytomegalovirus. In: Viral infections in obstetrics and gynecology, pp 35–56
- Ornoy A (2002) The effects of cytomegalovirus (CMV) infection during pregnancy on the developing human fetus. Harefuah 141:565–577
- Chung-Hua F, Chan K, Tsa C (1992) Effects of cytomegalovirus infections in pregnant women to fetuses: study with DNA–DNA hybridization method (with English abstract). Chin J Obstet Gynecol 380:355–358
- Nigro G, Adler SP, La Torre R, Best AM (2005) Passive immunization during pregnancy for congenital cytomegalovirus infection. N Eng J Med 353:1350–1362 CrossRef
- Congenital cytomegalovirus infection in pregnancy: a case report of fetal death in a CMV-infected woman
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Archives of Gynecology and Obstetrics
Volume 276, Issue 3 , pp 265-268
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Congenital infection
- Industry Sectors