Archives of Gynecology and Obstetrics

, Volume 275, Issue 5, pp 373–379

The efficacy of 2002 CDC guidelines in preventing perinatal group B Streptococcal vertical transmission: a prospective study

Authors

    • Department of Obstetrics and Gynaecology, San Martino HospitalUniversity of Genoa
  • Elisa Di Capua
    • Department of Obstetrics and Gynaecology, San Martino HospitalUniversity of Genoa
  • Simone Ferrero
    • Department of Obstetrics and Gynaecology, San Martino HospitalUniversity of Genoa
  • Emanuela Mistrangelo
    • Department of Obstetrics and Gynaecology, San Martino HospitalUniversity of Genoa
  • Alessandro Giannattasio
    • Department of PaediatricsGenoa University
  • Sandra Morano
    • Department of Obstetrics and Gynaecology, San Martino HospitalUniversity of Genoa
  • Nicola Ragni
    • Department of Obstetrics and Gynaecology, San Martino HospitalUniversity of Genoa
Original Article

DOI: 10.1007/s00404-006-0263-7

Cite this article as:
Lijoi, D., Capua, E.D., Ferrero, S. et al. Arch Gynecol Obstet (2007) 275: 373. doi:10.1007/s00404-006-0263-7

Abstract

Objectives

The aim of the current study is to evaluate the differences in the rate of perinatal group B streptococcal vertical transmission between women who correctly underwent the CDC 2002 guidelines and women who did not.

Methods

Two study groups: women who correctly underwent the CDC 2002 guidelines (study group 1) and women who did not (study group 2). Intrapartum chemoprophylaxis (IC) was administered to all pregnant women identified as GBS carrier. All newborns received, in the first hour of life, a culture based screening for GBS colonization.

Results

One thousand six hundred and sixty nine women were enrolled in the study. The 2002 CDC guidelines were correctly applied in 1273 (76.3%) subjects. There was no early-onset GBS disease. No statistically significant difference in the total number of colonized newborns between study group 1 (4.1%) and study group 2 (3.3%) was found. When the analysis was limited to women with positive GBS screening, a significant difference (P < 0.001) was observed in the number of colonized newborns between mothers who received IC during at least 4 h (group 1; 3.7%) and those who received an IC during less than 4 h (group 1; 12.3%).

Conclusion

The accurate application of the 2002 CDC guidelines is strongly supported but, to furthermore reduce the risk for GBS colonization and sepsis in the newborns, it appears desirable to identify additional and new prevention strategies.

Keywords

2002 CDC guidelinesGBS culture based screeningGBS vertical transmissionGroup B Streptococcus (GBS)Intrapartum chemoprophylaxis

Abbreviations

AAP

American Academy of Pediatrics

ACOG

American College of Obstetricians and Gynecologists

CDC

Centers for Disease Control and Prevention

EOGBS

Early-onset group B Streptococcus disease

g

Gram

GBS

Group B Streptococcus

IC

Intrapartum chemoprophylaxis

mg

Milligram

ml

Milliliter

n

Number

μg

Microgram

Copyright information

© Springer-Verlag 2006