Archives of Gynecology and Obstetrics

, Volume 274, Issue 6, pp 367–371

Cytochrome P2A13 and P1A1 gene polymorphisms are associated with the occurrence of uterine leiomyoma

Authors

    • Department of Obstetrics and GynecologyUlm University Medical Center
    • Department of Obstetrics and GynecologyFreiburg University Medical Center
    • Universitäts-Frauenklinik Ulm
  • H. Bettendorf
    • Department of Obstetrics and GynecologyFreiburg University Medical Center
  • D. Denschlag
    • Department of Obstetrics and GynecologyFreiburg University Medical Center
  • C. Keck
    • Department of Obstetrics and GynecologyFreiburg University Medical Center
  • D. Pietrowski
    • Department of Obstetrics and GynecologyFreiburg University Medical Center
Original Article

DOI: 10.1007/s00404-006-0201-8

Cite this article as:
Herr, D., Bettendorf, H., Denschlag, D. et al. Arch Gynecol Obstet (2006) 274: 367. doi:10.1007/s00404-006-0201-8

Abstract

Problem

To investigate the association between the occurrence of uterine leiomyoma and two SNPs of the CYP 2A13 and CYP 1A1 genes.

Method of study

Prospective case control study with 132 women with clinically and surgically diagnosed uterine leiomyoma and 260 controls. Genotyping was performed by polymerase chain reaction (PCR) based amplification of CYP 2A13 and CYP 1A1 genes, and restriction fragment length polymorphism (RFLP) analysis.

Results

Comparing women with uterine leiomyoma and controls, we demonstrate statistical significant differences of allele frequency and genotype distribution for the CYP 1A1 polymorphism (P = 0.025 and P = 0.046, respectively). Furthermore, for the CYP 2A13 polymorphism we found a significant difference concerning allele frequency (P = 0.033). However, for the genotype distribution, only borderline significance was observed (P = 0.064).

Conclusions

The CYP 2A13 and CYP 1A1 SNPs are associated with uterine leiomyoma in a Caucasian population and may contribute to the understanding of the pathogenic mechanisms of uterine leiomyoma.

Keywords

CYP 1A1CYP 2A13LeiomyomaPolymorphism

Copyright information

© Springer-Verlag 2006