, Volume 273, Issue 6, pp 331-336
Date: 15 Nov 2005

Relation between plasma adenosine and serum TSH levels in women with hyperemesis gravidarum

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Introduction: This study investigated the relation between adenosine and thyroid function associated with hyperemesis gravidarum. Methods: We examined 84 Japanese singleton pregnant women with an average age of 33.0±5.8 years at 9–12 weeks gestation being managed at our hospital. The patients were divided into three groups according to the severity of emesis: (1) those with hyperemesis gravidarum (nausea and vomiting with weight loss >5%, n=13), (2) those with emesis (nausea and vomiting with weight loss <5%, n=31), and (3) those with no symptoms as a control (n=40). Results: The average serum TSH levels in the emesis and hyperemesis groups were significantly higher than that in the control group (P<0.05). The average plasma adenosine level in the hyperemesis group was significantly higher than those in the control pregnant and emesis groups (P<0.05). There were no significant differences in plasma adenosine levels between the control pregnant and emesis groups. The serum TSH level showed significant correlations with weight loss (%) and plasma adenosine levels (P<0.05). Conclusions: Our findings support the possible role of adenosine in counteracting the further progression of hyperemesis gravidarum associated with gestational thyrotoxicosis.