Archives of Gynecology and Obstetrics

, Volume 271, Issue 3, pp 257–259

Prenatal and postnatal findings of acrania

  • S. Bianca
  • C. Ingegnosi
  • S. Auditore
  • A. Reale
  • M. G. Galasso
  • G. Bartoloni
  • A. Arancio
  • G. Ettore
Case Report

DOI: 10.1007/s00404-004-0621-2

Cite this article as:
Bianca, S., Ingegnosi, C., Auditore, S. et al. Arch Gynecol Obstet (2005) 271: 257. doi:10.1007/s00404-004-0621-2

Abstract

Introduction

Acrania is a rare congenital anomaly in which the flat bones of the cranial vault are partial or complete absent with complete but abnormal development of the cerebral hemispheres.

Case report

We report two cases, diagnosed prenatally by ultrasound and followed by medical pregnancy termination, one with isolated acrania and one with associated cleft lip and palate and spina bifida.

Discussion

The acrania pathogenesis is unknown and differential diagnosis should be made with other conditions like anencephaly and acalvaria. Genetic counselling is not easy because there is no evidence for a specific genetic origin, but the extreme rarity and sporadic nature suggests a low recurrence risk.

Keywords

AcraniaAncephalyCranial vaultPrenatal diagnosisFetal autopsy

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • S. Bianca
    • 1
    • 2
    • 3
  • C. Ingegnosi
    • 1
    • 2
  • S. Auditore
    • 3
  • A. Reale
    • 3
  • M. G. Galasso
    • 4
  • G. Bartoloni
    • 5
  • A. Arancio
    • 3
  • G. Ettore
    • 1
    • 3
  1. 1.Registro Siciliano Malformazioni CongeniteCataniaItaly
  2. 2.Dipartimento di PediatriaUniversità di CataniaCataniaItaly
  3. 3.Divisione di Ostetricia e GinecologiaAzienda Ospedaliera “Garibaldi”CataniaItaly
  4. 4.Servizio di Anatomia e Istologia PatologicaAzienda Ospedaliera “Garibaldi”CataniaItaly
  5. 5.U.O. di Anatomia PatologicaUniversità di CataniaCataniaItaly