Review

Archives of Dermatological Research

, Volume 289, Issue 1, pp 1-8

First online:

Cytokines and their effects on maturation, differentiation and migration of dendritic cells

  • H. JonuleitAffiliated withDepartment of Dermatology, University of Mainz, Langenbeckstr. 1, D-55131 Mainz, Germany Tel. 49-6131-173541; Fax 49-6131-176614
  • , Jürgen KnopAffiliated withDepartment of Dermatology, University of Mainz, Langenbeckstr. 1, D-55131 Mainz, Germany Tel. 49-6131-173541; Fax 49-6131-176614
  • , Alexander H. EnkAffiliated withDepartment of Dermatology, University of Mainz, Langenbeckstr. 1, D-55131 Mainz, Germany Tel. 49-6131-173541; Fax 49-6131-176614

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Abstract

In this review the role of cytokines in the maturation and migration of phenotypically and functionally diverse dendritic cell (DC) subpopulations is discussed and their role in the progress of differentiation from bone marrow progenitors to lymphoid DC is described. GM-CSF is the most important cytokine for the development of functional DC and acts in concert with a varying mixture of other cytokines such as IL-4, IL-1 and TNF-α to direct the development of individual DC subpopulations.

Key words Dendritic cell Langerhans cell Cytokines Dendritic cell differentiation