Archives of Dermatological Research

, Volume 306, Issue 9, pp 781–791

Association of FCGR2A-R/H131 polymorphism with susceptibility to systemic lupus erythematosus among Asian population: a meta-analysis of 20 studies

Authors

  • Rui Li
    • Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical University
    • Anhui Provincial Laboratory of Population Health and Major Disease Screening and DiagnosisAnhui Medical University
  • Hui Peng
    • The First Affiliated Hospital of Wannan Medical College
  • Gui-Mei Chen
    • School of Health ManagementAnhui Medical University
  • Chen-Chen Feng
    • Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical University
    • Anhui Provincial Laboratory of Population Health and Major Disease Screening and DiagnosisAnhui Medical University
  • Yu-Jing Zhang
    • Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical University
    • Anhui Provincial Laboratory of Population Health and Major Disease Screening and DiagnosisAnhui Medical University
  • Peng-Fei Wen
    • Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical University
    • Anhui Provincial Laboratory of Population Health and Major Disease Screening and DiagnosisAnhui Medical University
  • Li-Juan Qiu
    • Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical University
    • Anhui Provincial Laboratory of Population Health and Major Disease Screening and DiagnosisAnhui Medical University
  • Rui-Xue Leng
    • Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical University
    • Anhui Provincial Laboratory of Population Health and Major Disease Screening and DiagnosisAnhui Medical University
  • Hai-Feng Pan
    • Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical University
    • Anhui Provincial Laboratory of Population Health and Major Disease Screening and DiagnosisAnhui Medical University
    • Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical University
    • Anhui Provincial Laboratory of Population Health and Major Disease Screening and DiagnosisAnhui Medical University
Original Paper

DOI: 10.1007/s00403-014-1483-5

Cite this article as:
Li, R., Peng, H., Chen, G. et al. Arch Dermatol Res (2014) 306: 781. doi:10.1007/s00403-014-1483-5

Abstract

The results of studies on association between FCGR2A-R/H131 polymorphism and susceptibility to systemic lupus erythematosus (SLE) in the Asian population are controversial. To derive a more precise estimation on the genetic risk of FCGR2A-R/H131 variant for SLE in Asians, a meta-analysis was performed for genotypes R/R + R/H (dominant effect), R/R (recessive effect), and R allele in fixed/random effects models. Twenty studies involving 4,832 SLE patients and 6,190 controls were included. The meta-analysis showed that FCGR2A-R/H131 variant was associated with development of SLE in overall Asians both at allele or genotype level (R vs H, OR 1.201, 95 % CI 1.098–1.315; RR + RH vs HH, OR 1.369, 95 % CI 1.115–1.682; RR vs RH + HH, OR 1.305, 95 % CI 1.029–1.654). After stratification by ethnic, a significant association of R allele with susceptibility to SLE was observed in the Chinese population (R vs H, OR 1.104, 95 % CI 1.030–1.183). Evidence from subgroup analyses in non-Chinese populations (all Asians excluding Chinese population) also showed a significant association (R vs H, OR 1.354, 95 % CI 1.207–1.519; RR + RH vs HH, OR 1.705, 95 % CI 1.234–2.355). In addition, FCGR2A-R131 allele was associated with a 1.186-fold (95 % CI 1.043–1.349) greater risk for the occurrence of nephritis in the Asians population with SLE. After stratification by ethnic, this significant association was only consistently identified in non-Chinese populations (R vs H, OR 1.220, 95 % CI 1.002–1.486). In summary, FCGR2A-R/H131 polymorphism is associated with SLE and lupus nephritis in Asians.

Keywords

Systemic lupus erythematosusFCGR2APolymorphismMeta-analysis

Supplementary material

403_2014_1483_MOESM1_ESM.pdf (51 kb)
Supplementary material 1 (PDF 51 kb)

Copyright information

© Springer-Verlag Berlin Heidelberg 2014