Archives of Dermatological Research

, Volume 306, Issue 9, pp 781–791

Association of FCGR2A-R/H131 polymorphism with susceptibility to systemic lupus erythematosus among Asian population: a meta-analysis of 20 studies

  • Rui Li
  • Hui Peng
  • Gui-Mei Chen
  • Chen-Chen Feng
  • Yu-Jing Zhang
  • Peng-Fei Wen
  • Li-Juan Qiu
  • Rui-Xue Leng
  • Hai-Feng Pan
  • Dong-Qing Ye
Original Paper

DOI: 10.1007/s00403-014-1483-5

Cite this article as:
Li, R., Peng, H., Chen, G. et al. Arch Dermatol Res (2014) 306: 781. doi:10.1007/s00403-014-1483-5

Abstract

The results of studies on association between FCGR2A-R/H131 polymorphism and susceptibility to systemic lupus erythematosus (SLE) in the Asian population are controversial. To derive a more precise estimation on the genetic risk of FCGR2A-R/H131 variant for SLE in Asians, a meta-analysis was performed for genotypes R/R + R/H (dominant effect), R/R (recessive effect), and R allele in fixed/random effects models. Twenty studies involving 4,832 SLE patients and 6,190 controls were included. The meta-analysis showed that FCGR2A-R/H131 variant was associated with development of SLE in overall Asians both at allele or genotype level (R vs H, OR 1.201, 95 % CI 1.098–1.315; RR + RH vs HH, OR 1.369, 95 % CI 1.115–1.682; RR vs RH + HH, OR 1.305, 95 % CI 1.029–1.654). After stratification by ethnic, a significant association of R allele with susceptibility to SLE was observed in the Chinese population (R vs H, OR 1.104, 95 % CI 1.030–1.183). Evidence from subgroup analyses in non-Chinese populations (all Asians excluding Chinese population) also showed a significant association (R vs H, OR 1.354, 95 % CI 1.207–1.519; RR + RH vs HH, OR 1.705, 95 % CI 1.234–2.355). In addition, FCGR2A-R131 allele was associated with a 1.186-fold (95 % CI 1.043–1.349) greater risk for the occurrence of nephritis in the Asians population with SLE. After stratification by ethnic, this significant association was only consistently identified in non-Chinese populations (R vs H, OR 1.220, 95 % CI 1.002–1.486). In summary, FCGR2A-R/H131 polymorphism is associated with SLE and lupus nephritis in Asians.

Keywords

Systemic lupus erythematosusFCGR2APolymorphismMeta-analysis

Supplementary material

403_2014_1483_MOESM1_ESM.pdf (51 kb)
Supplementary material 1 (PDF 51 kb)

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Rui Li
    • 1
    • 2
  • Hui Peng
    • 3
  • Gui-Mei Chen
    • 4
  • Chen-Chen Feng
    • 1
    • 2
  • Yu-Jing Zhang
    • 1
    • 2
  • Peng-Fei Wen
    • 1
    • 2
  • Li-Juan Qiu
    • 1
    • 2
  • Rui-Xue Leng
    • 1
    • 2
  • Hai-Feng Pan
    • 1
    • 2
  • Dong-Qing Ye
    • 1
    • 2
  1. 1.Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical UniversityHefeiPeople’s Republic of China
  2. 2.Anhui Provincial Laboratory of Population Health and Major Disease Screening and DiagnosisAnhui Medical UniversityHefeiPeople’s Republic of China
  3. 3.The First Affiliated Hospital of Wannan Medical CollegeWuhuPeople’s Republic of China
  4. 4.School of Health ManagementAnhui Medical UniversityHefeiPeople’s Republic of China