Archives of Dermatological Research

, Volume 306, Issue 3, pp 305–307

No association between vitamin D intake and incident psoriasis among US women

  • Joseph F. Merola
  • Jiali Han
  • Tricia Li
  • Abrar A. Qureshi
Concise Communication

DOI: 10.1007/s00403-013-1426-6

Cite this article as:
Merola, J.F., Han, J., Li, T. et al. Arch Dermatol Res (2014) 306: 305. doi:10.1007/s00403-013-1426-6

Abstract

We investigated the association between dietary, supplementary and total vitamin D intake and incident psoriasis in women. A prospective study was performed of 70,437 US female nurses aged 47–74 enrolled in the Nurses’ Health Study who did not have psoriasis at baseline in 1994 and who completed semi-quantitative food frequency questionnaires in 1994, 1998, 2002 and 2006. The incidence of clinician-diagnosed psoriasis was ascertained and validated by self-reported questionnaires. 502 confirmed incident psoriasis cases were documented during 973,057 person-years of follow-up from 1994 June to 2008 June. Association between vitamin D intake and incident psoriasis was assessed using multivariable-adjusted cox regression analysis. After adjusting for age, smoking, body mass index, calorie intake, UV flux, exercise and alcohol use, there was no significant association between vitamin D intake (dietary, supplementary and total vitamin D) and the risk of incident psoriasis. Compared with women whose dietary vitamin D intake was <100 IU/day, multivariate relative risks for psoriasis was 1.13 (95 % CI 0.66–1.92) for ≥400 IU/day (P trend = 0.88). The multivariate relative risk for women who took supplementary vitamin D ≥400 IU/day was 1.18 (95 % CI 0.88–1.58) compared with women who did not take supplementary vitamin D. The multivariate risk for women who had total vitamin D intake of 300–399 IU/day was no different than at higher and lower doses of vitamin D intake. Our study does not support preventive roles of dietary or supplemental vitamin D intake for incident psoriasis.

Keywords

PsoriasisVitamin DEpidemiology

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Joseph F. Merola
    • 1
    • 3
  • Jiali Han
    • 1
    • 2
  • Tricia Li
    • 2
  • Abrar A. Qureshi
    • 1
    • 2
  1. 1.Brigham and Women’s Hospital, Harvard Medical SchoolDepartment of DermatologyBostonUSA
  2. 2.Channing Division of Network Medicine, Department of Medicine Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA
  3. 3. Division of Rheumatology, Department of Medicine, Harvard Medical SchoolBrigham and Women’s HospitalBostonUSA