Archives of Dermatological Research

, Volume 305, Issue 10, pp 945–950

Viewpoint on handling anti-TNF failure in psoriasis

Concise Communication

DOI: 10.1007/s00403-013-1418-6

Cite this article as:
Bracke, S. & Lambert, J. Arch Dermatol Res (2013) 305: 945. doi:10.1007/s00403-013-1418-6

Abstract

An association among the occurrence of antidrug antibodies (ADAs), diminished trough serum drug levels (TSDLs) and non-response or loss of response has been described for several tumor necrosis factor alpha (TNF) blocking agents in a variety of diseases, including psoriasis. In a series of ten psoriasis patients with primary or secondary failure, or adverse reactions during anti-TNF therapy, we measured ADAs and TSDLs in patient serum using radioimmunoassay and ELISA, respectively. By proposing a treatment algorithm derived from research in this field, we show that measuring ADAs and TSDLs in psoriasis patients provides a more structured approach to clinical decision making for psoriasis patients who fail anti-TNF therapy.

Keywords

PsoriasisBiologicsAnti-TNFImmunogenicityAnti-drug antibodies (ADA)Drug trough levels

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of DermatologyGhent University HospitalGhentBelgium