Archives of Dermatological Research

, Volume 304, Issue 10, pp 781–785

PGP 9.5 distribution patterns in biopsies from early lesions of atopic dermatitis

  • Lennart Emtestam
  • Lena Hagströmer
  • Ying-Chun Dou
  • Karin Sartorius
  • Olle Johansson
Original Paper

DOI: 10.1007/s00403-012-1246-0

Cite this article as:
Emtestam, L., Hagströmer, L., Dou, Y. et al. Arch Dermatol Res (2012) 304: 781. doi:10.1007/s00403-012-1246-0

Abstract

Peripheral nerve fibres are often increased in lesional skin of atopic dermatitis (AD) patients. We attempted to study nerve fibre profiles, using PGP 9.5 as neuronal marker, in early AD lesions in 10 patients, as compared to non-lesional skin in the same patients and skin from healthy controls. The number of PGP 9.5-positive nerve fibre profiles was not different in the biopsies taken from normal-looking AD skin and healthy controls. The total number of PGP 9.5-positive nerve fibre profiles in the whole skin sections was higher in both the epidermis and the dermis in the group of skin biopsies taken from early lesions of AD patients. Further, the number of epidermal PGP 9.5-positive dendritic cells was increased in AD skin. It seems reasonable that PGP 9.5-positive nerve fibres and PGP 9.5-positive dendritic cells have pathological roles in AD. The findings might serve as a basis for further studies in evaluating novel diagnostic and therapeutic approaches.

Keywords

Protein gene product 9.5Atopic dermatitis

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Lennart Emtestam
    • 1
  • Lena Hagströmer
    • 2
  • Ying-Chun Dou
    • 3
  • Karin Sartorius
    • 2
  • Olle Johansson
    • 3
  1. 1.Section of Dermatology I 43, Department of Medicine, Karolinska InstitutetHuddinge University HospitalStockholmSweden
  2. 2.Section of Dermatology, Department of Clinical Science and EducationKarolinska InstitutetStockholmSweden
  3. 3.The Experimental Dermatology Unit, Department of NeuroscienceKarolinska InstitutetStockholmSweden