Archives of Dermatological Research

, Volume 303, Issue 10, pp 763–769

Association of haptoglobin phenotypes with the development of Kaposi’s sarcoma in HIV patients

  • Reinhart Speeckaert
  • Bob Colebunders
  • Johan R. Boelaert
  • Lieve Brochez
  • Jos Van Acker
  • Filip Van Wanzeele
  • Robert Hemmer
  • Marijn M. Speeckaert
  • Chris Verhofstede
  • Marc De Buyzere
  • Vic Arendt
  • Jean Plum
  • Joris R. Delanghe
Short Communication

DOI: 10.1007/s00403-011-1161-9

Cite this article as:
Speeckaert, R., Colebunders, B., Boelaert, J.R. et al. Arch Dermatol Res (2011) 303: 763. doi:10.1007/s00403-011-1161-9

Abstract

Kaposi’s sarcoma (KS) is a rare cutaneous tumor caused by human herpes virus-8 (HHV-8) infection that preferentially develops in case of severe immunosuppression, such as in HIV/AIDS disease. Haptoglobin (Hp), a polymorphic multifunctional plasma protein, exerts several immunomodulatory effects and is characterized by a genetic polymorphism leading to three major phenotypes (Hp 1-1, Hp 2-1 and Hp 2-2). This study investigated the influence of Hp genetic polymorphism on the development of KS in HIV-positive patients. 661 HIV patients were enrolled in the study with a median age of 35 years and a median follow-up time of 57 months. Hp phenotyping was performed using hemoglobin-supplemented starch gel electrophoresis. In case of low Hp concentration high pressure gel permeation chromatography (HPGPC) was used. The Hp 1-1 phenotype was associated with a significant higher risk of KS compared to the combined group of Hp 2-1 and Hp 2-2 patients (p < 0.0005) which remained significant after adjustment for possible confounding variables (age, gender and AIDS status) (p < 0.001). In contrast, the Hp 2-1 phenotype carried the lowest risk. These findings point to the involvement of Hp phenotypes in the pathogenesis of KS, which may be due to a difference in skin immunosurveillance between the Hp phenotypes.

Keywords

Genetic polymorphism Haptoglobin HIV Kaposi’s sarcoma 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Reinhart Speeckaert
    • 1
  • Bob Colebunders
    • 2
  • Johan R. Boelaert
    • 3
  • Lieve Brochez
    • 1
  • Jos Van Acker
    • 4
  • Filip Van Wanzeele
    • 4
  • Robert Hemmer
    • 5
  • Marijn M. Speeckaert
    • 4
  • Chris Verhofstede
    • 4
  • Marc De Buyzere
    • 4
  • Vic Arendt
    • 5
  • Jean Plum
    • 4
  • Joris R. Delanghe
    • 4
  1. 1.Department of DermatologyGhent University HospitalGhentBelgium
  2. 2.Institute for Tropical MedicineAntwerp University HospitalAntwerpBelgium
  3. 3.Department of Nephrology and Infectious DiseasesAZ Sint-Jan BruggeBrugesBelgium
  4. 4.Department of Clinical ChemistryGhent University HospitalGhentBelgium
  5. 5.Centre Hospitalier de LuxembourgLuxembourgLuxembourg

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