Short Communication

Archives of Dermatological Research

, Volume 302, Issue 2, pp 145-149

First online:

Apolipoprotein ε4 allele is associated with psoriasis severity

  • Pablo Coto-SeguraAffiliated withDermatology II Department, Hospital Universitario Central de Asturias (HUCA)
  • , Eliecer CotoAffiliated withMolecular Genetics Department, HUCA
  • , Victoria AlvarezAffiliated withMolecular Genetics Department, HUCA
  • , Blanca MoralesAffiliated withMolecular Genetics Department, HUCA
  • , Javier Soto-SánchezAffiliated withDermatology II Department, Hospital Universitario Central de Asturias (HUCA)
  • , A. I. CoraoAffiliated withMolecular Genetics Department, HUCA
  • , Jorge Santos-JuanesAffiliated withDermatology II Department, Hospital Universitario Central de Asturias (HUCA) Email author 

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Many reports provided strong evidence of the influence of genetic factors in the pathogenesis of psoriasis (Ps). A higher prevalence of lipid disorders in psoriatic patients has been reported. Because apolipoprotein E (apoE) is involved in lipid metabolism, APOE gene variants could be candidates to influence Ps-risk. However, data about the potential influence of the APOE genotypes in Ps are inconclusive. Our objective was to investigate the relationship between the common APOE-ε2/ε3/ε4 variation and Ps in a Caucasian population. Our study involved 331 unrelated Ps-patients and 400 healthy controls. Patients and controls were genotyped for the APOE-ε2/ε3/ε4 polymorphism, and allele and genotype frequencies were statistically compared between the two groups and between patients according to disease severity. Mean lipid values were also compared between the APOE genotypes. Allele and genotype frequencies did not differ between patients and controls. APOE-ε4 carriers were significantly more frequent in patients with severe Ps compared to controls (P = 0.003) and to non-severe Ps (P = 0.017). No significant difference in mean lipid values was found between the APOE genotypes. The APOE-ε4 allele could be a risk factor for developing a severe form of psoriasis.


Apolipoprotein E DNA polymorphisms Genetic association Psoriasis Inflammation Lipid disorders