Archives of Dermatological Research

, Volume 302, Issue 2, pp 145–149

Apolipoprotein ε4 allele is associated with psoriasis severity

  • Pablo Coto-Segura
  • Eliecer Coto
  • Victoria Alvarez
  • Blanca Morales
  • Javier Soto-Sánchez
  • A. I. Corao
  • Jorge Santos-Juanes
Short Communication

DOI: 10.1007/s00403-009-1002-2

Cite this article as:
Coto-Segura, P., Coto, E., Alvarez, V. et al. Arch Dermatol Res (2010) 302: 145. doi:10.1007/s00403-009-1002-2

Abstract

Many reports provided strong evidence of the influence of genetic factors in the pathogenesis of psoriasis (Ps). A higher prevalence of lipid disorders in psoriatic patients has been reported. Because apolipoprotein E (apoE) is involved in lipid metabolism, APOE gene variants could be candidates to influence Ps-risk. However, data about the potential influence of the APOE genotypes in Ps are inconclusive. Our objective was to investigate the relationship between the common APOE-ε2/ε3/ε4 variation and Ps in a Caucasian population. Our study involved 331 unrelated Ps-patients and 400 healthy controls. Patients and controls were genotyped for the APOE-ε2/ε3/ε4 polymorphism, and allele and genotype frequencies were statistically compared between the two groups and between patients according to disease severity. Mean lipid values were also compared between the APOE genotypes. Allele and genotype frequencies did not differ between patients and controls. APOE-ε4 carriers were significantly more frequent in patients with severe Ps compared to controls (P = 0.003) and to non-severe Ps (P = 0.017). No significant difference in mean lipid values was found between the APOE genotypes. The APOE-ε4 allele could be a risk factor for developing a severe form of psoriasis.

Keywords

Apolipoprotein E DNA polymorphisms Genetic association Psoriasis Inflammation Lipid disorders 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Pablo Coto-Segura
    • 1
  • Eliecer Coto
    • 2
  • Victoria Alvarez
    • 2
  • Blanca Morales
    • 2
  • Javier Soto-Sánchez
    • 1
  • A. I. Corao
    • 2
  • Jorge Santos-Juanes
    • 1
  1. 1.Dermatology II DepartmentHospital Universitario Central de Asturias (HUCA)OviedoSpain
  2. 2.Molecular Genetics DepartmentHUCAOviedoSpain

Personalised recommendations