Archives of Dermatological Research

, Volume 301, Issue 1, pp 83–86

Type I interferon-associated cytotoxic inflammation in cutaneous lupus erythematosus

  • Joerg Wenzel
  • Sabine Zahn
  • Thomas Bieber
  • Thomas Tüting
Review

DOI: 10.1007/s00403-008-0892-8

Cite this article as:
Wenzel, J., Zahn, S., Bieber, T. et al. Arch Dermatol Res (2009) 301: 83. doi:10.1007/s00403-008-0892-8

Abstract

Inappropriate activation of innate immune mechanisms, in particular of the type I interferon (IFN) system, is regarded to play an important role in the pathogenesis of lupus erythematosus (LE). Type I IFN serum levels have been shown to correlate with the disease activity in systemic LE and additionally play a proinflammatory role in the development of LE skin lesions. Recent studies demonstrated a close morphological association between the expression pattern of IFN-inducible chemokines (MxA, CXCL10) and typical histological features of cutaneous LE. These and other studies suggest that a complex network of IFN-associated cytokines, chemokines and adhesion molecules orchestrates and promotes tissue injury observed in LE skin.

Keywords

SkinLupusCXCL9CXCL10CXCR3

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Joerg Wenzel
    • 1
  • Sabine Zahn
    • 1
  • Thomas Bieber
    • 1
  • Thomas Tüting
    • 1
  1. 1.Department of DermatologyUniversity of BonnBonnGermany