Archives of Dermatological Research

, Volume 300, Issue 2, pp 69–80

Parthenolide-depleted Feverfew (Tanacetum parthenium) protects skin from UV irradiation and external aggression

Authors

  • Katharine Martin
    • Johnson & Johnson Skin Research CenterCPPW, a unit of Johnson & Johnson Consumer Companies, Inc.
  • Runa Sur
    • Johnson & Johnson Skin Research CenterCPPW, a unit of Johnson & Johnson Consumer Companies, Inc.
  • Frank Liebel
    • Johnson & Johnson Skin Research CenterCPPW, a unit of Johnson & Johnson Consumer Companies, Inc.
  • Neena Tierney
    • Johnson & Johnson Skin Research CenterCPPW, a unit of Johnson & Johnson Consumer Companies, Inc.
  • Peter Lyte
    • Johnson & Johnson Skin Research CenterCPPW, a unit of Johnson & Johnson Consumer Companies, Inc.
  • Michelle Garay
    • Johnson & Johnson Skin Research CenterCPPW, a unit of Johnson & Johnson Consumer Companies, Inc.
  • Thierry Oddos
    • Johnson & Johnson Skin Research CenterCPPW, a unit of Johnson & Johnson Consumer Companies, Inc.
  • Mike Anthonavage
    • Johnson & Johnson Skin Research CenterCPPW, a unit of Johnson & Johnson Consumer Companies, Inc.
  • Stan Shapiro
    • Johnson & Johnson Skin Research CenterCPPW, a unit of Johnson & Johnson Consumer Companies, Inc.
    • Johnson & Johnson Skin Research CenterCPPW, a unit of Johnson & Johnson Consumer Companies, Inc.
    • Johnson & Johnson Consumer and Personal Products Worldwide
Original Paper

DOI: 10.1007/s00403-007-0818-x

Cite this article as:
Martin, K., Sur, R., Liebel, F. et al. Arch Dermatol Res (2008) 300: 69. doi:10.1007/s00403-007-0818-x

Abstract

The skin is under continual assault from a variety of damaging environmental factors such as ultraviolet irradiation and atmospheric pollutants, and as organisms age the cumulative damage exceeds the capacity of endogenous antioxidant defenses resulting in chronic inflammation and premature aging. Botanical extracts such as Feverfew containing naturally occurring antioxidants could replenish the depleted cutaneous stores and perhaps forestall these degenerative changes. A parthenolide-depleted extract of Feverfew (PD-Feverfew), which was free of sensitization potential, was found to possess free radical scavenging activity against a wide range of reactive oxygen species and with greater activity than Vitamin C. In vitro, PD-Feverfew restored cigarette smoke-mediated depletion of cellular thiols, attenuated the formation of UV-induced hydrogen peroxide and reduced pro-inflammatory cytokine release. In vivo, topical PD-Feverfew reduced UV-induced epidermal hyperplasia, DNA damage and apoptosis. In a clinical study PD-Feverfew treatment significantly reduced erythema versus placebo 24 h post-UV exposure. Through the ability to scavenge free radicals, preserve endogenous antioxidant levels, reduce DNA damage and induce DNA repair enzymes, which can help repair damaged DNA, parthenolide-depleted extract of Feverfew may protect skin from the numerous external aggressions encountered daily by the skin and reduce the damage to oxidatively challenged skin.

Keywords

FeverfewFlavonoidsOxidative stressParthenolideReactive oxygen speciesInflammation

Abbreviations

ROS

Reactive oxygen species

UVA

Ultraviolet A

UVB

Ultraviolet B

Copyright information

© The Author(s) 2007