Archives of Dermatological Research

, Volume 298, Issue 3, pp 107–112

Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population

Authors

  • Sen Yang
    • Institute of Dermatology and Department of Dermatology at No.1 HospitalAnhui Medical University
    • The Key Laboratory of Gene Resource Utilization for Severe DiseasesMinistry of Education
  • Kai-Lin Yan
    • Institute of Dermatology and Department of Dermatology at No.1 HospitalAnhui Medical University
    • The Key Laboratory of Gene Resource Utilization for Severe DiseasesMinistry of Education
    • Institute of Dermatology and Department of Dermatology at No.1 HospitalAnhui Medical University
    • The Key Laboratory of Gene Resource Utilization for Severe DiseasesMinistry of Education
  • Feng-Li Xiao
    • Institute of Dermatology and Department of Dermatology at No.1 HospitalAnhui Medical University
    • The Key Laboratory of Gene Resource Utilization for Severe DiseasesMinistry of Education
  • Xing Fan
    • Institute of Dermatology and Department of Dermatology at No.1 HospitalAnhui Medical University
    • The Key Laboratory of Gene Resource Utilization for Severe DiseasesMinistry of Education
  • Min Gao
    • Institute of Dermatology and Department of Dermatology at No.1 HospitalAnhui Medical University
    • The Key Laboratory of Gene Resource Utilization for Severe DiseasesMinistry of Education
  • Yong Cui
    • Institute of Dermatology and Department of Dermatology at No.1 HospitalAnhui Medical University
    • The Key Laboratory of Gene Resource Utilization for Severe DiseasesMinistry of Education
  • Peng-Guang Wang
    • Institute of Dermatology and Department of Dermatology at No.1 HospitalAnhui Medical University
    • The Key Laboratory of Gene Resource Utilization for Severe DiseasesMinistry of Education
  • Guo-Long Zhang
    • Institute of Dermatology and Department of Dermatology at No.1 HospitalAnhui Medical University
    • The Key Laboratory of Gene Resource Utilization for Severe DiseasesMinistry of Education
  • Liang-Dan Sun
    • Institute of Dermatology and Department of Dermatology at No.1 HospitalAnhui Medical University
    • The Key Laboratory of Gene Resource Utilization for Severe DiseasesMinistry of Education
  • Zhi-Min Wang
    • Chinese National Human Genome Center at Shanghai
    • State Key Laboratory of Genetic Engineering and Center for Anthropological Studies, School of Life SciencesFudan University
  • Da-Zhi Wang
    • Chinese National Human Genome Center at Shanghai
  • Kai-Yue Zhang
    • Chinese National Human Genome Center at Shanghai
    • Chinese National Human Genome Center at Shanghai
  • Jian-Jun Liu
    • Institute of Dermatology and Department of Dermatology at No.1 HospitalAnhui Medical University
    • The Key Laboratory of Gene Resource Utilization for Severe DiseasesMinistry of Education
    • Genome Institute of Singapore
Original Paper

DOI: 10.1007/s00403-006-0670-4

Cite this article as:
Yang, S., Yan, K., Zhang, X. et al. Arch Dermatol Res (2006) 298: 107. doi:10.1007/s00403-006-0670-4

Abstract

Several recent studies have demonstrated the possible involvement of the microsomal glutathione S-transferase 2 (MGST2) gene in the pathogenesis of psoriasis. The objectives of this work are to determine whether the genetic polymorphisms of the MGST2 gene were associated with an increased risk of psoriasis in Chinese patients. We first characterized the linkage disequilibrium pattern within MGST2 and identified single-nucleotide polymorphisms (SNPs) for tagging common genetic variants. Genotype- and haplotype-based analyses were then performed by genotyping the Tag SNPs in a large-scale sample of cases and controls. We characterized the linkage disequilibrium pattern within MGST2 using 12 densely distributed SNPs and identified 6 SNPs for tagging common genetic variants. We then performed an association analysis by genotyping the six SNPs in 552 cases and 384 controls, but none of the genotype- and haplotype-based analyses revealed significant evidence for association. We also performed family-based association analysis by genotyping the six SNPs in 95 trios; no evidence for association was identified. Our comprehensive genetic analysis of MGST2 common variants in a large Chinese sample of psoriasis did not provide any supporting evidence for MGST2 to be the susceptibility gene within the PSORS9 locus.

Keywords

Association analysisHaplotypeLinkage disequilibriumMGST2Psoriasis vulgarisTDT

Copyright information

© Springer-Verlag 2006