Original Paper

Archives of Dermatological Research

, Volume 298, Issue 3, pp 107-112

Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population

  • Sen YangAffiliated withInstitute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical UniversityThe Key Laboratory of Gene Resource Utilization for Severe Diseases, Ministry of Education
  • , Kai-Lin YanAffiliated withInstitute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical UniversityThe Key Laboratory of Gene Resource Utilization for Severe Diseases, Ministry of Education
  • , Xue-Jun ZhangAffiliated withInstitute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical UniversityThe Key Laboratory of Gene Resource Utilization for Severe Diseases, Ministry of Education Email author 
  • , Feng-Li XiaoAffiliated withInstitute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical UniversityThe Key Laboratory of Gene Resource Utilization for Severe Diseases, Ministry of Education
  • , Xing FanAffiliated withInstitute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical UniversityThe Key Laboratory of Gene Resource Utilization for Severe Diseases, Ministry of Education
  • , Min GaoAffiliated withInstitute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical UniversityThe Key Laboratory of Gene Resource Utilization for Severe Diseases, Ministry of Education
  • , Yong CuiAffiliated withInstitute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical UniversityThe Key Laboratory of Gene Resource Utilization for Severe Diseases, Ministry of Education
  • , Peng-Guang WangAffiliated withInstitute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical UniversityThe Key Laboratory of Gene Resource Utilization for Severe Diseases, Ministry of Education
  • , Guo-Long ZhangAffiliated withInstitute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical UniversityThe Key Laboratory of Gene Resource Utilization for Severe Diseases, Ministry of Education
    • , Liang-Dan SunAffiliated withInstitute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical UniversityThe Key Laboratory of Gene Resource Utilization for Severe Diseases, Ministry of Education
    • , Zhi-Min WangAffiliated withChinese National Human Genome Center at ShanghaiState Key Laboratory of Genetic Engineering and Center for Anthropological Studies, School of Life Sciences, Fudan University
    • , Da-Zhi WangAffiliated withChinese National Human Genome Center at Shanghai
    • , Kai-Yue ZhangAffiliated withChinese National Human Genome Center at Shanghai
    • , Wei HuangAffiliated withChinese National Human Genome Center at Shanghai Email author 
    • , Jian-Jun LiuAffiliated withInstitute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical UniversityThe Key Laboratory of Gene Resource Utilization for Severe Diseases, Ministry of EducationGenome Institute of Singapore

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Several recent studies have demonstrated the possible involvement of the microsomal glutathione S-transferase 2 (MGST2) gene in the pathogenesis of psoriasis. The objectives of this work are to determine whether the genetic polymorphisms of the MGST2 gene were associated with an increased risk of psoriasis in Chinese patients. We first characterized the linkage disequilibrium pattern within MGST2 and identified single-nucleotide polymorphisms (SNPs) for tagging common genetic variants. Genotype- and haplotype-based analyses were then performed by genotyping the Tag SNPs in a large-scale sample of cases and controls. We characterized the linkage disequilibrium pattern within MGST2 using 12 densely distributed SNPs and identified 6 SNPs for tagging common genetic variants. We then performed an association analysis by genotyping the six SNPs in 552 cases and 384 controls, but none of the genotype- and haplotype-based analyses revealed significant evidence for association. We also performed family-based association analysis by genotyping the six SNPs in 95 trios; no evidence for association was identified. Our comprehensive genetic analysis of MGST2 common variants in a large Chinese sample of psoriasis did not provide any supporting evidence for MGST2 to be the susceptibility gene within the PSORS9 locus.

Keywords

Association analysis Haplotype Linkage disequilibrium MGST2 Psoriasis vulgaris TDT