Archives of Dermatological Research

, Volume 297, Issue 4, pp 147–153

Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin

Authors

  • A. Barel
    • Faculty of Physical Education and PhysiotherapyVrije Universiteit Brussel
    • Department of Pharmaceutical Sciences Faculty of Pharmaceutical, Biomedical and Veterinary SciencesUniversity of Antwerp
  • A. Timchenko
    • Faculty of Physical Education and PhysiotherapyVrije Universiteit Brussel
  • K. De. Paepe
    • Faculty of Medicine and PharmacyVrije Universiteit Brussel
  • N. Demeester
    • Department of Pharmaceutical Sciences Faculty of Pharmaceutical, Biomedical and Veterinary SciencesUniversity of Antwerp
  • V. Rogiers
    • Faculty of Medicine and PharmacyVrije Universiteit Brussel
  • P. Clarys
    • Faculty of Physical Education and PhysiotherapyVrije Universiteit Brussel
  • D. Vanden Berghe
    • Department of Pharmaceutical Sciences Faculty of Pharmaceutical, Biomedical and Veterinary SciencesUniversity of Antwerp
Original Paper

DOI: 10.1007/s00403-005-0584-6

Cite this article as:
Barel, A., Calomme, M., Timchenko, A. et al. Arch Dermatol Res (2005) 297: 147. doi:10.1007/s00403-005-0584-6

Abstract

Chronic exposure of the skin to sunlight causes damage to the underlying connective tissue with a loss of elasticity and firmness. Silicon (Si) was suggested to have an important function in the formation and maintenance of connective tissue. Choline-stabilized orthosilicic acid (“ch-OSA”) is a bioavailable form of silicon which was found to increase the hydroxyproline concentration in the dermis of animals. The effect of ch-OSA on skin, nails and hair was investigated in a randomized, double blind, placebo-controlled study. Fifty women with photodamaged facial skin were administered orally during 20 weeks, 10 mg Si/day in the form of ch-OSA pellets (n=25) or a placebo (n=25). Noninvasive methods were used to evaluate skin microrelief (forearm), hydration (forearm) and mechanical anisotropy (forehead). Volunteers evaluated on a virtual analog scale (VAS, “none=0, severe=3”) brittleness of hair and nails. The serum Si concentration was significantly higher after a 20-week supplementation in subjects with ch-OSA compared to the placebo group. Skin roughness parameters increased in the placebo group (Rt:+8%; Rm: +11%; Rz: +6%) but decreased in the ch-OSA group (Rt: −16%; Rm: −19%; Rz: −8%). The change in roughness from baseline was significantly different between ch-OSA and placebo groups for Rt and Rm. The difference in longitudinal and lateral shear propagation time increased after 20 weeks in the placebo group but decreased in the ch-OSA group suggesting improvement in isotropy of the skin. VAS scores for nail and hair brittleness were significantly lower after 20 weeks in the ch-OSA group compared to baseline scores. Oral intake of ch-OSA during the 20 weeks results in a significant positive effect on skin surface and skin mechanical properties, and on brittleness of hair and nails.

Keywords

Photodamaged skinSiliconOrthosilicic acidNailsHair

Copyright information

© Springer-Verlag 2005