Archives of Orthopaedic and Trauma Surgery

, Volume 121, Issue 1, pp 65–66

Effect of preoperative chemotherapy on the outcome of surgical treatment of vertebral tuberculosis: retrospective analysis of 434 cases

Authors

  • Emin Alici
    • Department of Orthopedics, Dokuz Eylül University Hospital, I˙zmir, Turkey
  • Ömer Akçali
    • Department of Orthopedics, Dokuz Eylül University Hospital, I˙zmir, Turkey
  • Hasan Tatari
    • Department of Orthopedics, Dokuz Eylül University Hospital, I˙zmir, Turkey
  • İ Günal
    • Department of Orthopedics, Dokuz Eylül University Hospital, I˙zmir, Turkey
Clinical and Experimental Forum

DOI: 10.1007/s004020000163

Cite this article as:
Alici, E., Akçali, Ö., Tatari, H. et al. Arch Orth Traum Surg (2001) 121: 65. doi:10.1007/s004020000163

Abstract

A retrospective analysis of 434 patients with vertebral tuberculosis who were treated surgically was performed with special reference to the preoperative duration of chemotherapy. Of these, 376 underwent 4 weeks of a chemotherapy regimen with isoniazid, rifampin and ethamburol, and in 2 re-activation of the disease was observed. The remaining 58 underwent operation for neurological impairment with 6–18 h of the same chemotherapy regimen, and in no case did re-activation occur. These results suggest a shorter duration of chemotherapy may be utilised in all patients undergoing surgical treatment for vertebral tuberculosis, providing a thorough debridement is performed, leaving no necrotic or infected tissue behind.

Copyright information

© Springer-Verlag Berlin Heidelberg 2001