Acta Neuropathologica

, Volume 99, Issue 5, pp 547–554

Temporal lobe epilepsy with and without psychosis: exploration of hippocampal pathology including that in subpopulations of neurons defined by their content of immunoreactive calcium-binding proteins

  • J. Suckling
  • H. Roberts
  • M. Walker
  • J. R. Highley
  • P. Fenwick
  • J. Oxbury
  • M. M. Esiri
Regular paper

DOI: 10.1007/s004010051159

Cite this article as:
Suckling, J., Roberts, H., Walker, M. et al. Acta Neuropathol (2000) 99: 547. doi:10.1007/s004010051159

Abstract

We have investigated relationships between hippocampal/temporal lobe neuropathology and psychosis in subjects with temporal lobe epilepsy, paying particular attention to possible differences in density of hippocampal neurons immunoreactive for calcium-binding proteins. There was a trend for a greater prevalence of left handedness in the psychotic (n = 6) than the non-psychotic (n = 26) cases (P = 0.0504). Psychotic cases also differed from non-psychotic ones in having: (1) more focal lesions outside the hippocampus (P = 0.006); (2) less severe CA1 neuron loss (P = 0.015); and (3) a trend, after Bonferroni correction, for a higher density of calbindin-immunoreactive neurons in the CA4 (P = 0.022). An additional finding was that dentate granule cell dispersion was significantly associated with the presence of a reduced density of calretinin-immunoreactive neurons in CA4 (P = 0.002) and with a more severe loss of CA4 neurons visible with Nissl stain (P = 0.003). Thus, cases of temporal lobe epilepsy with psychosis were distinguishable on the basis of a higher density of calbindin-reactive neurons in CA4 as well as on more general aspects of their pathology.

Key words EpilepsyPsychosisHippocampusPathologyCalcium-binding proteins

Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • J. Suckling
    • 1
  • H. Roberts
    • 1
  • M. Walker
    • 1
  • J. R. Highley
    • 1
  • P. Fenwick
    • 2
  • J. Oxbury
    • 2
  • M. M. Esiri
    • 1
  1. 1.Departments of Neuropathology and Clinical Neurology, Oxford University, Radcliffe Infirmary, Oxford OX2 6HE, UK e-mail: margaret.esiri@clneuro.ox.ac.uk, Tel.: +44-1865-224403, Fax: +44-1865-224508GB
  2. 2.Departments of Neurology Department, Radcliffe Infirmary NHS Trust, Oxford OX2 6HE, UKGB