Case report

Acta Neuropathologica

, Volume 98, Issue 1, pp 107-110

Hippocampal sclerosis with hypertrophy of end folium pyramidal cells

  • Maria ThomAffiliated withDepartment of Neuropathology, Institute of Neurology, Queen Square, London WC1N 3BG, UK Fax: +44-171-916-9546
  • , C. D’ArrigoAffiliated withDepartment of Neuropathology, Institute of Neurology, Queen Square, London WC1N 3BG, UK Fax: +44-171-916-9546
  • , F. ScaravilliAffiliated withDepartment of Neuropathology, Institute of Neurology, Queen Square, London WC1N 3BG, UK Fax: +44-171-916-9546

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Abstract

Mesial temporal lobectomy for the treatment of intractable temporal lobe seizures may show dual pathologies for example hippocampal sclerosis (HCS) combined with a malformation. In a lobectomy specimen from a 40-year-old female with typical radiological and pathological features of HCS, an additional histopathological finding was the presence of hypertrophic pyramidal cells in the dentate hilus, in which cytoplasmic accumulations of phosphorylated neurofilament were demonstrated. Although these cells closely resembled dysplastic nerve cells of cortical dysplasia, we argue that the cytoskeletal abnormalities observed are a result of ongoing alterations to hippocampal circuitry in an evolving HCS.

Key words Hippocampal Sclerosis Neuronal Cytomegaly