Acta Neuropathologica

, Volume 96, Issue 5, pp 445–452

Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy

Authors

  • K. Wakabayashi
    • Brain Disease Research Center, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951-8585, Japan e-mail: koichi@bri.niigata-u.ac.jp, Tel.: +81-25-227-0673, Fax: +81-25-227-0817
  • Shintaro Hayashi
    • Department of Pathology, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951-8585, Japan
  • Akiyoshi Kakita
    • Department of Pathology, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951-8585, Japan
  • Mitsunori Yamada
    • Department of Pathology, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951-8585, Japan
  • Yasuko Toyoshima
    • Department of Pathology, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951-8585, Japan
  • Makoto Yoshimoto
    • Molecular Biology Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co. Ltd., Ohmiya, Saitama 330-0031, Japan
  • Hitoshi Takahashi
    • Department of Pathology, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951-8585, Japan
Express communication

DOI: 10.1007/s004010050918

Cite this article as:
Wakabayashi, K., Hayashi, S., Kakita, A. et al. Acta Neuropathol (1998) 96: 445. doi:10.1007/s004010050918

Abstract

Recently, we have shown that the precursor of the non-Aβ component of Alzheimer’s disease amyloid (NACP), also known as α-synuclein, is a major component of Lewy bodies (LBs) as well as neuronal and glial cytoplasmic inclusions in multiple system atrophy (MSA). To elucidate whether the accumulation of NACP is specific to LB disease and MSA, we further studied 83 autopsied cases with various neurological disorders, using anti-NACP antibodies. In LB disease, NACP immunoreactivity was present in all of the LBs and Lewy neurites in both the central and peripheral nervous systems, the pale bodies in the substantia nigra, and dystrophic neurites in the hippocampal CA2/3 region. Immunoelectron microscopy revealed that the reaction product was localized within filamentous structures and associated granular structures. In MSA, NACP immunoreactivity was found in the intracytoplasmic inclusions of both neuronal and oligodendroglial cells, neuronal intranuclear inclusions, and swollen neuronal processes. No NACP immunoreactivity was found in a variety of other neuronal or glial inclusions in other disorders, including Alzheimer’s disease, Pick’s disease, progressive supranuclear palsy, corticobasal degeneration, motor neuron disease and triplet-repeat diseases. These findings strongly suggest that the accumulation of NACP is a cytopathological feature common to LB disease and MSA.

Key wordsα-SynucleinNACPLewy bodyParkinson’s diseaseMultiple system atrophy

Copyright information

© Springer-Verlag Berlin Heidelberg 1998