Acta Neuropathologica

, Volume 96, Issue 5, pp 439–444

NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy

Authors

  • K. Arima
    • Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156-8585, Japan e-mail: arima@prit.go.jp, Tel.: +81-3-3304-5701, Fax: +81-3-3329-8035
  • Kenji Uéda
    • Department of Neurochemistry, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156-8585, Japan
  • Nobuhiko Sunohara
    • Department of Neurology, National Center Hospital for Mental, Nervous, and Muscular Disorders, NCNP, Kodaira, Tokyo 187-8551, Japan
  • Kenji Arakawa
    • Department of Neurology, National Center Hospital for Mental, Nervous, and Muscular Disorders, NCNP, Kodaira, Tokyo 187-8551, Japan
  • Shigeo Hirai
    • Department of Laboratory Medicine, National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry (NCNP), Kodaira, Tokyo 187-8551, Japan
  • Minako Nakamura
    • Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156-8585, Japan e-mail: arima@prit.go.jp, Tel.: +81-3-3304-5701, Fax: +81-3-3329-8035
  • Haruko Tonozuka-Uehara
    • Department of Neurochemistry, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156-8585, Japan
  • Mitsuru Kawai
    • Department of Laboratory Medicine, National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry (NCNP), Kodaira, Tokyo 187-8551, Japan
Express communication

DOI: 10.1007/s004010050917

Cite this article as:
Arima, K., Uéda, K., Sunohara, N. et al. Acta Neuropathol (1998) 96: 439. doi:10.1007/s004010050917

Abstract

We examined neuronal cytoplasmic inclusions (NCIs) and oligodendrocytic glial cytoplasmic inclusions (GCIs) in the pontine nuclei in multiple system atrophy (MSA) using antibodies against the non-amyloid β component of Alzheimer’s disease amyloid precursor protein (NACP/α-synuclein). Our immunohistochemical study revealed that anti-NACP antibodies labeled both NCIs and GCIs. Immunoelectron microscopy showed that positive reaction products were localized on the 15- to 30-nm-thick filamentous components of NCIs and GCIs. The present study demonstrates that NACP is associated with cytoplasmic inclusions of MSA, and suggests a role of NACP in abnormal filament aggregation in neuronal degeneration.

Key words NACPSynucleinMultiple systematrophyNeuronal cytoplasmic inclusionsGlialcytoplasmic inclusions
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© Springer-Verlag Berlin Heidelberg 1998