Acta Neuropathologica

, Volume 94, Issue 6, pp 519–524

Amyloid precursor-like protein 1 accumulates in neuritic plaques in Alzheimer’s disease

  • Thomas A. Bayer
  • Krzysztof Paliga
  • Sascha Weggen
  • O. D. Wiestler
  • Konrad Beyreuther
  • Gerd Multhaup
Express communication

DOI: 10.1007/s004010050745

Cite this article as:
Bayer, T., Paliga, K., Weggen, S. et al. Acta Neuropathol (1997) 94: 519. doi:10.1007/s004010050745
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Abstract

The Alzheimer’s disease (AD) β-amyloid precursor protein (APP) and the amyloid precursor-like protein 1 (APLP1) and 2 (APLP2) are members of a superfamily of proteins that appear functionally related. Although APLPs are highly homologous to APP in the N- and C-terminal domains, they lack the βA4/amyloid peptide, i.e., the main constituent of neuritic plaques in AD. To assess a potential role of APLP1 in AD, we have determined its immunohistochemical distribution in human hippocampal formation, a structure which is strongly affected in AD, and compared it with APP immunoreactivity. There was a considerable overlap of APP and APLP1 regional expression patterns. Significant APLP1 immunoreactivity was observed in neuritic plaques. Large pyramidal neurons of the subiculum showed an accumulation of APLP1 protein in their dendritic compartment. Some astrocytes elicited perinuclear APLP1 staining, but this was observed in both AD and control brains. These findings raise the possibility that APLP1 may contribute to the pathogenesis of AD-associated neurodegeneration.

Key words Alzheimer’s disease Amyloid precursor-like protein 1 Amyloid precursor protein Plaques 

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Thomas A. Bayer
    • 1
  • Krzysztof Paliga
    • 2
  • Sascha Weggen
    • 1
  • O. D. Wiestler
    • 1
  • Konrad Beyreuther
    • 2
  • Gerd Multhaup
    • 2
  1. 1.Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, D-53105 Bonn, Germany Tel.: 49-228-287-6602; Fax: 49-228-287-4331; e-mail: neuropath@uni-bonn.deDE
  2. 2.ZMBH, Im Neuenheimer Feld 282, D-69120 Heidelberg, GermanyDE

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