Acta Neuropathologica

, Volume 94, Issue 3, pp 287–289

The intermediolateral nucleus and Clarke’s column in Parkinson’s disease

  • K. Wakabayashi
  • Hitoshi Takahashi
Short original communication

DOI: 10.1007/s004010050705

Cite this article as:
Wakabayashi, K. & Takahashi, H. Acta Neuropathol (1997) 94: 287. doi:10.1007/s004010050705


Histological and morphometrical observations of the intermediolateral nucleus (IML) and Clarke’s column at the levels of the upper and lower thoracic segments (T2 and T9) were carried out in 25 patients with Parkinson’s disease (PD) and 25 age-matched control subjects. The average numbers of neurons in the IML at T2 and T9 in the PD patients were 69% and 57% of those in the controls, respectively. Lewy bodies were found in the remaining IML neurons in 24 of 25 cases of PD. On the other hand, the number of neurons in Clarke’s column in the PD patients was not reduced. Considering that autonomic symptoms are one of the cardinal clinical features in PD, the present finding of IML neuron loss with formation of Lewy bodies appears to be of great importance.

Key words Parkinson’s diseaseIntermediolateralnucleusClarke’s columnQuantitative examinationLewy body

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • K. Wakabayashi
    • 1
  • Hitoshi Takahashi
    • 2
  1. 1.Brain Disease Research Center, Niigata University, 1 Asahimachi, Niigata 951, Japan Tel.: 81-25-223-6161, ext. 5221; Fax: 81-25-223-7503 e-mail:
  2. 2.Department of Pathology, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951, JapanJP