Acta Neuropathologica

, Volume 93, Issue 1, pp 7–12

Neurofibrillary tangles in the dentate granule cells of patients with Alzheimer’s disease, Lewy body disease and progressive supranuclear palsy

Authors

  • K. Wakabayashi
    • Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093-0624, USA Tel.: 1-619-534-1376; Fax: 1-619-534-6232; e-mail: emasliah@UCSD.edu
  • Lawrence A. Hansen
    • Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093-0624, USA Tel.: 1-619-534-1376; Fax: 1-619-534-6232; e-mail: emasliah@UCSD.edu
  • Inez Vincent
    • Department of Pathology and Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
  • Margaret Mallory
    • Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093-0624, USA Tel.: 1-619-534-1376; Fax: 1-619-534-6232; e-mail: emasliah@UCSD.edu
  • E. Masliah
    • Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093-0624, USA Tel.: 1-619-534-1376; Fax: 1-619-534-6232; e-mail: emasliah@UCSD.edu
Regular paper

DOI: 10.1007/s004010050576

Cite this article as:
Wakabayashi, K., Hansen, L., Vincent, I. et al. Acta Neuropathol (1996) 93: 7. doi:10.1007/s004010050576

Abstract

Recent studies have shown that the dentate granular cells of the hippocampus are affected in patients with Alzheimer’s disease (AD). To gain a better understanding of the cytoskeletal alterations in these cells, we carried out immunocytochemical and immunoelectron microscopic analysis of the dentate gyrus of patients with primary degenerative dementias, using a monoclonal antibody against paired helical filaments (TG3). This antibody labeled a large number of spherical inclusions in the dentate granule cells of patients with AD and its Lewy body variant (LBV). These inclusions consisted of straight tubular structures (about 18–25 nm in diameter), similar to those found in progressive supranuclear palsy (PSP). These inclusions, although in a smaller number, were also found in demented patients with PSP, but not in those with diffuse Lewy body disease or age-matched controls. These findings indicate that the neurofibrillary alterations in the dentate granule cells of patients with AD, LBV and PSP share cytoskeletal similarities.

Key words Neurofibrillary tangleDentate granule cellAlzheimer’s diseaseLewy body diseaseProgressivesupranuclear palsy

Copyright information

© Springer-Verlag Berlin Heidelberg 1996