Acta Neuropathologica

, Volume 92, Issue 6, pp 608–613

Is β-APP a marker of axonal damage in short-surviving head injury?

  • K. J. McKenzie
  • D. R. McLellan
  • S. M. Gentleman
  • W. L. Maxwell
  • T. A. Gennarelli
  • D. I. Graham
Regular paper

DOI: 10.1007/s004010050568

Cite this article as:
McKenzie, K., McLellan, D., Gentleman, S. et al. Acta Neuropathol (1996) 92: 608. doi:10.1007/s004010050568

Abstract

β-Amyloid precursor protein (β-APP), a normal constituent of neurons which is conveyed by fast axonal transport, has been found to be a useful marker for axonal damage in cases of fatal head injury. Immunocytochemistry for β-APP is a more sensitive technique for identifying axonal injury than conventional silver impregnation. This study was designed to determine how quickly evidenc of axonal damage and bulb formation appears. Using this method a variety of brain areas were studied from 55 patients who died within 24 h of a head injury. Immunocytochemical evidence of axonal injury was first detected after 2 h survival, axonal bulbs were first identified after 3 h survival, and the amount of axonal damage and axonal bulb formation increased the longer the survival time.

Key words Head injury Axonal bulbs β-amyloid precursor protein (β-APP) Immunocytochemistry Diffuse axonal injury 

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • K. J. McKenzie
    • 1
  • D. R. McLellan
    • 1
  • S. M. Gentleman
    • 2
  • W. L. Maxwell
    • 3
  • T. A. Gennarelli
    • 4
  • D. I. Graham
    • 1
  1. 1.Department of Neuropathology, University of Glasgow, Glasgow, UKGB
  2. 2.Department of Anatomy, Charing Cross and Westminster Medical School, London, UKGB
  3. 3.Laboratory of Human Anatomy, University of Glasgow, Glasgow, UKGB
  4. 4.Department of Neurosurgery, Medical College of Pennsylvania and Hahnemann University, Philadelphia, Pennsylvania, USAUS
  5. 5.Department of Neuropathology, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital NHS Trust, Glasgow G51 4TF, UK Tel.: 0141-201 2113/2046: Fax: 0141-201 2998GB

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