Acta Neuropathologica

, Volume 92, Issue 2, pp 197–201

Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis

  • H. Braak
  • E. Braak
Short original communication

DOI: 10.1007/s004010050508

Cite this article as:
Braak, H. & Braak, E. Acta Neuropathol (1996) 92: 197. doi:10.1007/s004010050508


The pattern of neurofibrillary changes which gradually develops in the course of Alzheimer’s disease bears a striking resemblance to the inverse sequence of cortical myelination. Factors released by oligodendrocytes exert a strong influence upon nerve cells and suppress disordered neuritic outgrowth. It is suggested that the lack of such factors due to premature dysfunction of oligodendrocytes leads to alterations of the neuronal cytoskeleton and eventually to the appearance of Alzheimer-type neurofibrillary changes.

Key words OligodendrocytesMyelinationAlzheimer’s diseaseNeurofibrillary tanglesNeuropilthreads

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • H. Braak
    • 1
  • E. Braak
    • 1
  1. 1.Department of Anatomy, J. W. Goethe University, Theodor Stern Kai 7, D-60590 Frankfurt/Main, Germany Tel.: 49-69-6301-6900; Fax: 49-69-6301-6425DE