Acta Neuropathologica

, Volume 91, Issue 6, pp 578–586

Immunohistochemistry of primary central nervous system malignant rhabdoid tumors: report of five cases and review of the literature

  • Bettina Behring
  • Wolfgang Brück
  • Hans H. Goebel
  • Julianne Behnke
  • Arnulf Pekrun
  • Hans-Jürgen Christen
  • H. A. Kretzschmar
Regular paper

DOI: 10.1007/s004010050470

Cite this article as:
Behring, B., Brück, W., Goebel, H. et al. Acta Neuropathol (1996) 91: 578. doi:10.1007/s004010050470

Abstract

Malignant rhabdoid tumors (MRT) are characterized by a typical light microscopic morphology with uniformly round tumor cells, vacuolated cytoplasm with occasional round, hyaline intracytoplasmic, periodic acid-Schiff-positive inclusions, vesicular nuclei with prominent nucleoli and positive immunoreactivity for vimentin. The histogenesis of MRT is controversial. Five cases of primary central nervous system (CNS) rhabdoid tumors in children are presented. Immunohistochemical, light and electron microscopic features are compared with primary CNS malignant rhabdoid tumors reported in the literature. Expression of various neurofilaments in our cases of primary CNS rhabdoid tumors was prominent and we therefore favor a neural differentiation of extrarenal intracerebral rhabdoid tumors.

Key words Malignant rhabdoid tumorImmunohistochemistryCentral nervous system

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • Bettina Behring
    • 1
  • Wolfgang Brück
    • 1
  • Hans H. Goebel
    • 2
  • Julianne Behnke
    • 3
  • Arnulf Pekrun
    • 4
  • Hans-Jürgen Christen
    • 5
  • H. A. Kretzschmar
    • 1
  1. 1.Institute of Neuropathology, University of Göttingen, Robert-Koch-Strasse 40, D-37075 Göttingen, Germany Tel.: 49 551-392700; Fax: 49 551-398472DE
  2. 2.Department of Neuropathology, University of Mainz, Mainz, GermanyDE
  3. 3.Department of Neurosurgery, University of Göttingen, Göttingen, GermanyDE
  4. 4.Department of Pediatrics, University of Göttingen, Göttingen, GermanyDE
  5. 5.Department of Neuropediatrics, University of Göttingen, Göttingen, GermanyDE