Acta Neuropathologica

, Volume 100, Issue 3, pp 337–341

Human herpesvirus 6-meningoencephalitis in an HIV patient with progressive multifocal leukoencephalopathy

  • M. Ito
  • J. V. Baker
  • D. J. Mock
  • A. D. Goodman
  • B. M. Blumberg
  • D. A. Shrier
  • J. M. Powers
Case report

DOI: 10.1007/s004010000198

Cite this article as:
Ito, M., Baker, J., Mock, D. et al. Acta Neuropathol (2000) 100: 337. doi:10.1007/s004010000198
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Abstract

Human herpesvirus 6 (HHV6) has been reported as a rare cause of meningoencephalitis and leukoencephalitis. We present an HIV-infected patient with ¶lesions of progressive multifocal leukoencephalopathy (PML), but also meningoencephalitis apparently due to HHV6. Immunohistochemistry for HHV6 antigens and in situ polymerase chain reaction for HHV6 genome showed many positive lymphocytes and microglia in the meningeal and cortical lesions. More importantly, dead and dying neurons were conspicuous; some were undergoing neuronophagia and some displayed evidence of HHV6 infection. A pathogenic role for this almost universal, and usually commensal, virus in inflammatory brain lesions and PML is briefly discussed.

Key words Meningoencephalitis Human herpesvirus 6 Lymphocyte Progressive multifocal leukoencephalopathy HIV 

Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • M. Ito
    • 1
  • J. V. Baker
    • 2
  • D. J. Mock
    • 3
  • A. D. Goodman
    • 2
  • B. M. Blumberg
    • 2
  • D. A. Shrier
    • 4
  • J. M. Powers
    • 1
  1. 1.Department of Pathology, University of Rochester School of Medicine and Dentistry, Box 626, 601 Elmwood Avenue, Rochester, NY 14642, USA Fax: +1-716-2731027US
  2. 2.Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USAUS
  3. 3.Department of Medicine/Infectious Diseases, University of Rochester School of Medicine and Dentistry, Rochester, New York, USAUS
  4. 4.Division of Neuroradiology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USAUS

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