Acta Neuropathologica

, Volume 126, Issue 5, pp 683–697

CSF α-synuclein improves diagnostic and prognostic performance of CSF tau and Aβ in Alzheimer’s disease

  • Jon B. Toledo
  • Ane Korff
  • Leslie M. Shaw
  • John Q. Trojanowski
  • Jing Zhang
Original Paper

DOI: 10.1007/s00401-013-1148-z

Cite this article as:
Toledo, J.B., Korff, A., Shaw, L.M. et al. Acta Neuropathol (2013) 126: 683. doi:10.1007/s00401-013-1148-z

Abstract

Alzheimer’s disease (AD) and Lewy body diseases (LBD), e.g., Parkinson’s disease (PD) dementia and dementia with Lewy bodies (DLB), are common causes of geriatric cognitive impairments. In addition, AD and LBD are often found in the same patients at autopsy; therefore, biomarkers that can detect the presence of both pathologies in living subjects are needed. In this investigation, we report the assessment of α-synuclein (α-syn) in cerebrospinal fluid (CSF) and its association with CSF total tau (t-tau), phosphorylated tau181 (p-tau181), and amyloid beta1-42 (Aβ1-42) in subjects of the Alzheimer’s Disease Neuroimaging Initiative (ADNI; n = 389), with longitudinal clinical assessments. A strong correlation was noted between α-syn and t-tau in controls, as well as in patients with AD and mild cognitive impairment (MCI). However, the correlation is not specific to subjects in the ADNI cohort, as it was also seen in PD patients and controls enrolled in the Parkinson’s Progression Markers Initiative (PPMI; n = 102). A bimodal distribution of CSF α-syn levels was observed in the ADNI cohort, with high levels of α-syn in the subjects with abnormally increased t-tau values. Although a correlation was also noted between α-syn and p-tau181, there was a mismatch (α-syn–p-tau181-Mis), i.e., higher p-tau181 levels accompanied by lower α-syn levels in a subset of ADNI patients. We hypothesize that this α-syn–p-tau181-Mis is a CSF signature of concomitant LBD pathology in AD patients. Hence, we suggest that inclusion of measures of CSF α-syn and calculation of α-syn–p-tau181-Mis improves the diagnostic sensitivity/specificity of classic CSF AD biomarkers and better predicts longitudinal cognitive changes.

Keywords

Alzheimer’s disease Parkinson’s disease Dementia with Lewy body Cerebrospinal fluid Amyloid β Tau α-Synuclein 

Supplementary material

401_2013_1148_MOESM1_ESM.docx (64 kb)
Supplementary material 1 (DOCX 65 kb)

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Jon B. Toledo
    • 1
  • Ane Korff
    • 2
  • Leslie M. Shaw
    • 1
  • John Q. Trojanowski
    • 1
  • Jing Zhang
    • 2
  1. 1.Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease ResearchUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.Department of PathologyUniversity of Washington School of MedicineSeattleUSA