, Volume 114, Issue 3, pp 299-303
Date: 03 May 2007

More frequent Lewy bodies but less frequent Alzheimer-type lesions in multiple system atrophy as compared to age-matched control brains

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Multiple system atrophy (MSA), a largely sporadic adult-onset progressive synucleinopathy, is divided into two clinicopathologic subtypes: MSA-P [striatonigral degeneration (SND) with predominant Parkinsonian features] and MSA-C [olivopontocerebellar atrophy (OPCA) with predominant cerebellar ataxia], whereas autonomic dysfunction common to all forms of MSA and referred to previously as Shy-Drager syndrome (SDS), has been discouraged in the new consensus criteria [6]. Neuropathology, in addition to multisystem neurodegeneration involving the striatonigral and the ponto-cerebello-olivary systems in variable degrees and overlap [10], is hallmarked by α-synuclein positive glial cytoplasmic inclusions (GCI) mainly in oligodendroglia, the demonstration of which is required in the diagnosis of definite MSA and cause anatomically selective neuronal loss, gliosis, and myelin pathology [13]. Less frequent neuronal and astroglial cytoplasmic inclusions of similar composition, rare ubiquitin-posi