Acta Neuropathologica

, Volume 113, Issue 1, pp 23–31

The distribution of cerebrovascular amyloid in Alzheimer’s disease varies with ApoE genotype

  • Dimitri Trembath
  • John F. Ervin
  • Lucy Broom
  • Mari Szymanski
  • Kathleen Welsh-Bohmer
  • Carl Pieper
  • Christine M. Hulette
Original Paper

DOI: 10.1007/s00401-006-0162-9

Cite this article as:
Trembath, D., Ervin, J.F., Broom, L. et al. Acta Neuropathol (2007) 113: 23. doi:10.1007/s00401-006-0162-9

Abstract

We performed a comparative study to assess cerebral amyloid angiopathy and ApoE genotype in cases of Alzheimer’s disease (AD). Ten ApoE 3,3 and ten ApoE 4,4 AD brains, as well as ten normal control brains, were selected after matching for age, sex, and duration of disease. Sections of middle frontal and inferior parietal cortex including white matter sections were stained with an antibody against amyloid beta (Aβ), and extensive analysis of arteriolar Aβ deposition was performed using digital image analysis. Quantification of the staining revealed a larger cross-section of arteriolar walls occupied by Aβ in ApoE 4,4 and ApoE 3,3 AD subjects compared to controls. Our results show Aβ deposition in gray matter and white matter arterioles was predominantly found in ApoE 4,4 brains and, overall, Aβ deposition was greatest in these cases. This observation implies that there is greater vascular amyloid deposition (particularly in the white matter arterioles) in ApoE 4,4 AD individuals compared to ApoE 3,3 AD. These observations may give insight into the etiology behind the increased risk for AD associated with the ApoE-ε4 allele and the pathogenesis of vascular Aβ deposition.

Keywords

Alzheimer’s disease (AD)Cerebral amyloid angiopathy (CAA)ApoEAmyloid beta (Aβ)Cerebral arterioles

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Dimitri Trembath
    • 1
  • John F. Ervin
    • 2
  • Lucy Broom
    • 2
  • Mari Szymanski
    • 2
  • Kathleen Welsh-Bohmer
    • 3
  • Carl Pieper
    • 4
  • Christine M. Hulette
    • 5
  1. 1.Department of NeurosurgeryJohns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Department of Medicine (Neurology)Duke University Medical CenterDurhamUSA
  3. 3.Department of PsychiatryDuke University Medical CenterDurhamUSA
  4. 4.Department of Biostatistics and BioinformaticsDuke University Medical CenterDurhamUSA
  5. 5.Department of PathologyDuke University Medical CenterDurhamUSA