Acta Neuropathologica

, Volume 113, Issue 2, pp 107–117

Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease

Review Article

DOI: 10.1007/s00401-006-0156-7

Cite this article as:
Jellinger, K.A. & Attems, J. Acta Neuropathol (2007) 113: 107. doi:10.1007/s00401-006-0156-7


Neurofibrillary tangle predominant dementia (NFTPD) is a subset of late onset dementia, clinically different from traditional “plaque and tangle” Alzheimer disease (AD): later onset, shorter duration, less severe cognitive impairment, and almost absence of ApoE ε4. Neuropathology reveals abundant allocortical neurofibrillary pathology with no or few isocortical tau lesions, absence of neuritic plaques, absence or scarcity of amyloid deposits, but neurofibrillary changes comprising both 3 and 4 repeat (3R and 4R) tau immunohistochemistry are not significantly different from those in classical AD. Comparing 51 autopsy cases of NFTPD with 244 classical AD subjects, the nosology of NFTPD and its differences from AD are discussed.


Senile dementia with tanglesAlzheimer disease3 and 4 repeat tau isoformsTauopathyDifferential diagnosisNeuropathology

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Institute of Clinical NeurobiologyViennaAustria
  2. 2.Department of PathologyOWS Hospital (JA)ViennaAustria